Suspension flow in microfluidic devices — A review of experimental techniques focussing on concentration and velocity gradients
| العنوان: | Suspension flow in microfluidic devices — A review of experimental techniques focussing on concentration and velocity gradients |
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| المؤلفون: | Frank J. Vergeldt, Remko M. Boom, C.G.P.H. Schroën, R.G.M. van der Sman, A.M.C. van Dinther |
| المصدر: | Advances in Colloid and Interface Science 173 (2012) Advances in Colloid and Interface Science, 173, 23-34 |
| بيانات النشر: | Elsevier BV, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Magnetic Resonance Spectroscopy, Materials science, Microfluidics, fluorescence correlation spectroscopy, Nanotechnology, Fluorescence correlation spectroscopy, confocal microscopy, electrical-impedance tomography, Suspension (chemistry), multiphase flows, Colloid and Surface Chemistry, Suspensions, particle image velocimetry, Electric Impedance, Laser-Doppler Flowmetry, Particle Size, Physical and Theoretical Chemistry, Food Process Engineering, Electrical impedance tomography, VLAG, Microscopy, Confocal, laser-doppler anemometry, Surfaces and Interfaces, Microfluidic Analytical Techniques, brownian suspension, pressure-driven flow, nuclear-magnetic-resonance, Particle image velocimetry, Positron-Emission Tomography, Food Technology, neutron-radiography, Particle, Particle size, Biological system, Communication channel |
| الوصف: | Microfluidic devices are an emerging technology for processing suspensions in e.g. medical applications, pharmaceutics and food. Compared to larger scales, particles will be more influenced by migration in microfluidic devices, and this may even be used to facilitate segregation and separation. In order to get most out of these completely new technologies, methods to experimentally measure (or compute) particle migration are needed to gain sufficient insights for rational design. However, the currently available methods only allow limited access to particle behaviour. In this review we compare experimental methods to investigate migration phenomena that can occur in microfluidic systems when operated with natural suspensions, having typical particle diameters of 0.1 to 10 µm. The methods are used to monitor concentration and velocity profiles of bidisperse and polydisperse suspensions, which are notoriously difficult to measure due to the small dimensions of channels and particles. Various methods have been proposed in literature: tomography, ultrasound, and optical analysis, and here we review and evaluate them on general dimensionless numbers related to process conditions and channel dimensions. Besides, eleven practical criteria chosen such that they can also be used for various applications, are used to evaluate the performance of the methods. We found that NMR and CSLM, although expensive, are the most promising techniques to investigate flowing suspensions in microfluidic devices, where one may be preferred over the other depending on the size, concentration and nature of the suspension, the dimensions of the channel, and the information that has to be obtained. The paper concludes with an outlook on future developments of measurement techniques. |
| وصف الملف: | application/pdf; application/octet-stream |
| تدمد: | 0001-8686 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3470c883ccab4cb291868462512b9ae https://doi.org/10.1016/j.cis.2012.02.003 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....b3470c883ccab4cb291868462512b9ae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00018686 |
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