A multi-residue method by supercritical fluid chromatography coupled with tandem mass spectrometry method for the analysis of chiral and non-chiral chemicals of emerging concern in environmental samples
| العنوان: | A multi-residue method by supercritical fluid chromatography coupled with tandem mass spectrometry method for the analysis of chiral and non-chiral chemicals of emerging concern in environmental samples |
|---|---|
| المؤلفون: | Jack Rice, Anneke Lubben, Barbara Kasprzyk-Hordern |
| المصدر: | Analytical and Bioanalytical Chemistry |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Detection limit, Analyte, Chromatography, Mass spectrometry, Resolution (mass spectrometry), 010401 analytical chemistry, Environment, 010501 environmental sciences, Supercritical fluid chromatography, 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, Chiral column chromatography, Wastewater, Environmental science, Effluent, Research Paper, Chiral chromatography, Chemicals of emerging concern, 0105 earth and related environmental sciences |
| الوصف: | This manuscript presents the development, validation and application of a multi-residue supercritical fluid chromatography coupled with tandem mass spectrometry method for the analysis of 140 chiral and non-chiral chemicals of emerging concern in environmental samples, with 81 compounds being fully quantitative, 14 semi-quantitative and 45 qualitative, validated according to European Medicine Agency (EMA) guidelines (European Medicines Agency 2019). One unified LC-MS method was used to analyse all analytes, which were split into three injection methods to ensure sufficient peak resolution. The unified method provided an average of 113% accuracy and 4.5% precision across the analyte range. Limits of detection were in the range of 35 pg L−1–0.7 μg L−1, in both river water and wastewater, with an average LOD of 33 ng L−1. The method was combined with solid-phase extraction and applied in environmental samples, showing very good accuracy and precision, as well as excellent chromatographic resolution of a range of chiral enantiomers including beta-blockers, benzodiazepines and antidepressants. The method resulted in quantification of 75% of analytes in at least two matrices, and 56% in the trio of environmental matrices of river water, effluent wastewater and influent wastewater, enabling its use in monitoring compounds of environmental concern, from their sources of origin through to their discharge into the environment. Electronic supplementary material The online version of this article (10.1007/s00216-020-02780-9) contains supplementary material, which is available to authorized users. |
| تدمد: | 1618-2650 1618-2642 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34feb14c4f540331956ba8a1ca64db3 https://doi.org/10.1007/s00216-020-02780-9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b34feb14c4f540331956ba8a1ca64db3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16182650 16182642 |
|---|