Experimental Studies on the Inhibition of Adenovirus-ING4-OSM Therapy on Nasopharyngeal Carcinoma Proliferation In Vitro and In Vivo
| العنوان: | Experimental Studies on the Inhibition of Adenovirus-ING4-OSM Therapy on Nasopharyngeal Carcinoma Proliferation In Vitro and In Vivo |
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| المؤلفون: | B C Sun, Chengyong Zhou, Qinghong Yan, Zeli Han, Jinghong Zhang |
| المصدر: | Cell Biochemistry and Biophysics. 70:1573-1578 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Genetic enhancement, Genetic Vectors, Biophysics, Nasopharyngeal neoplasm, Cell Cycle Proteins, Oncostatin M, Biology, Transfection, medicine.disease_cause, Biochemistry, Adenoviridae, Mice, In vivo, Cell Line, Tumor, otorhinolaryngologic diseases, medicine, Animals, Humans, Homeodomain Proteins, Mice, Knockout, Nasopharyngeal Carcinoma, Tumor Suppressor Proteins, Carcinoma, fungi, Nasopharyngeal Neoplasms, Genetic Therapy, Cell Biology, General Medicine, medicine.disease, In vitro, stomatognathic diseases, Treatment Outcome, Nasopharyngeal carcinoma, Immunology, Cancer research, biology.protein |
| الوصف: | In the present study, the effects of the co-transfer of the tumor growth inhibitor 4 gene (ING4) together with the Oncostatin M (OSM) were investigated on tumor regression and subsequent tumor recurrence. We constructed a recombinant adenovirus carrying ING4 and OSM, which could induce high-level expression of these three genes in NPC CNE-1 cells. Ad-ING4, Ad-OSM and Ad-ING4-OSM infection all inhibited the growth of CNE-1 cells in vitro, while the Ad-ING4-OSM exerted the strongest inhibitory effect. In CNE-1 xenograft tumor models mice, an intratumoral injection of Ad-ING4, Ad-OSM and Ad-ING4-OSM resulted in a reduced tumor burden, compared to normal saline controls. Therefore, we suggested that the introduction of adenovirus-mediated ING4 and OSM genes could synergistically decrease the recurrence or metastases and develop a control of NPC tumors, which advocate a promising therapeutic future in NPC treatment. |
| تدمد: | 1559-0283 1085-9195 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36c17532ba61021145edbc11df5cdb0 https://doi.org/10.1007/s12013-014-0097-z |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....b36c17532ba61021145edbc11df5cdb0 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15590283 10859195 |
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