The Addition of Low-dose Thalidomide to Bortezomib and Dexamethasone for Refractory Multiple Myeloma
| العنوان: | The Addition of Low-dose Thalidomide to Bortezomib and Dexamethasone for Refractory Multiple Myeloma |
|---|---|
| المؤلفون: | Shigeo Hashimoto, Toshio Yano, Naoko Sato, Takashi Kuroha, Tatsuo Furukawa |
| المصدر: | Internal Medicine |
| بيانات النشر: | Japanese Society of Internal Medicine, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Cyclophosphamide, Combination therapy, Antineoplastic Agents, Case Report, dexamethasone, 03 medical and health sciences, 0302 clinical medicine, Refractory, hemic and lymphatic diseases, Internal medicine, Internal Medicine, medicine, Humans, Bone pain, Multiple myeloma, Dexamethasone, Aged, Bortezomib, business.industry, bortezomib, General Medicine, Middle Aged, medicine.disease, Thalidomide, multiple myeloma, Treatment Outcome, 030104 developmental biology, 030220 oncology & carcinogenesis, Female, medicine.symptom, business, Immunosuppressive Agents, medicine.drug |
| الوصف: | Five cases were treated by adding daily low-dose thalidomide (50 mg) to bortezomib and dexamethasone therapy for refractory multiple myeloma. This therapy was effective in four cases, with an improvement of bone pain and regression of M-protein. One case was treated with cyclophosphamide, thalidomide, and dexamethasone, adding bortezomib after starting the three-drug combination therapy. This patient has remained in a stable disease state since the beginning of this therapy. Regarding the other four cases, a partial response and a prolonged survival for approximately one year were noted. Peripheral neuropathy did not increase after thalidomide addition. Adding low-dose thalidomide may safely improve the responses for multiple myeloma refractory to bortezomib and dexamethasone. |
| تدمد: | 1349-7235 0918-2918 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e3f4713d7bc74b6535f7bcc5fa4145 https://doi.org/10.2169/internalmedicine.55.6470 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b3e3f4713d7bc74b6535f7bcc5fa4145 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497235 09182918 |
|---|