Effect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot study
| العنوان: | Effect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot study |
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| المؤلفون: | Simona Panunzi, Venanzio Valenza, M Di Mugno, M Runfola, Geltrude Mingrone, A Scarfone, Daniele Gui, M Mutignani, P L Spada |
| المصدر: | Alimentary pharmacology & therapeutics 23(5) (2006): 675–680. info:cnr-pdr/source/autori:Gui, D.; Mingrone, G.; Valenza, V.; Spada, P.L.; Mutignani, M.; Runfola, M.; Scarfone, A.; Di Mugno, M.; Panunzi, S./titolo:Effect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot study/doi:/rivista:Alimentary pharmacology & therapeutics/anno:2006/pagina_da:675/pagina_a:680/intervallo_pagine:675–680/volume:23(5) |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, media_common.quotation_subject, medicine.medical_treatment, Gastric motility, Pilot Projects, Satiation, Gastroenterology, Injections, Eating, Sex Factors, Double-Blind Method, Weight loss, Internal medicine, Weight Loss, medicine, Pyloric Antrum, Humans, Pharmacology (medical), Obesity, Botulinum Toxins, Type A, Saline, Antrum, media_common, Hepatology, Gastric emptying, business.industry, Stomach, Appetite, Middle Aged, Botulinum toxin, Endocrinology, medicine.anatomical_structure, Treatment Outcome, Gastric Emptying, Neuromuscular Agents, Patient Satisfaction, Female, medicine.symptom, business, medicine.drug |
| الوصف: | Summary Background A potential approach to the treatment of morbid obesity is reduction of gastric emptying to achieve satiety. Botulinum toxin A (Btx-A) is a long-acting inhibitor of acetylcholine-mediated peristalsis, which is mainly responsible for gastric motility. Aim To investigate whether botulinum toxin A, injected in the antrum of obese patients, delays gastric emptying. Methods In a double_blind study, 18 healthy obese subjects (body mass index >30) were randomized into three groups (BTX133, BTX200 and Saline); they received Btx-A133U, Btx-A200U, or saline under endoscopic control. Gastric emptying was tested by scintigraphy before and 10 days after treatment. Body weight variations and appetite sensation were recorded after 5 weeks. Results Fourteen patients completed the study. The botulinum toxin A-treated groups showed weight reduction, which was not statistically significant. The effects on gastric emptying were variable. Most of the botulinum toxin A treated patients reported a reduced appetite. Conclusion This pilot clinical trial suggests potential activity of botulinum toxin A for the manipulation of appetite. |
| تدمد: | 0269-2813 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f3cde8e4bee682f30ab78fc714a1e9 https://pubmed.ncbi.nlm.nih.gov/16480407 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....b3f3cde8e4bee682f30ab78fc714a1e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02692813 |
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