التفاصيل البيبلوغرافية
العنوان:
The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors
المؤلفون:
Jianmin Wang , John J. Harrington , Daniel P. Silver , Bayard Huck , Kurt R. Brunden , Christina Leventhal , Bruce Sherf , L. Nathan Tumey , Tom Dent , Steven M. Murphy , Elizabeth Ann Gleason , Andrew Bailey , Sherry Boozer , Stephen Rundlett , Youssef L. Bennani
المصدر:
Bioorganicmedicinal chemistry letters . 14(19)
سنة النشر:
2004
مصطلحات موضوعية:
chemistry.chemical_classification , biology , DNA damage , DNA repair , Flap Endonucleases , Organic Chemistry , Clinical Biochemistry , Flap structure-specific endonuclease 1 , Pharmaceutical Science , Base excision repair , Biochemistry , Endonuclease , chemistry.chemical_compound , Butyrates , Structure-Activity Relationship , Enzyme , chemistry , Drug Discovery , biology.protein , Molecular Medicine , Flap endonuclease , Enzyme Inhibitors , Molecular Biology , DNA
الوصف:
There have been several recent reports of chemopotentiation via inhibition of DNA repair processes. Flap endonuclease 1 (FEN1) is a key enzyme involved in base excision repair (BER), a primary pathway utilized by mammalian cells to repair DNA damage. In this report, we describe the identification and SAR of a series of 2,4-diketobutyric acid FEN1 inhibitors.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4314bdb4a4d7541f2470c537d28b002 https://pubmed.ncbi.nlm.nih.gov/15341951
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....b4314bdb4a4d7541f2470c537d28b002
قاعدة البيانات:
OpenAIRE
