Pretreatment Lymph Node Metastasis as a Prognostic Significance in Cervical Cancer: Comparison between Disease Status
| العنوان: | Pretreatment Lymph Node Metastasis as a Prognostic Significance in Cervical Cancer: Comparison between Disease Status |
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| المؤلفون: | Chel Hun Choi, E Sun Paik, Yoo-Young Lee, Jun Hyeok Kang, Soo Young Jeong, Duk-Soo Bae, Jeong-Won Lee, Tae-Joong Kim, Hyea Park, Byoung-Gie Kim, Myeong Seon Kim |
| المصدر: | Cancer Research and Treatment : Official Journal of Korean Cancer Association |
| بيانات النشر: | Korean Cancer Association, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Uterine cervical neoplasms, Neoplasm metastasis, 03 medical and health sciences, Tumor Status, 0302 clinical medicine, Internal medicine, Parametrium, Humans, Medicine, Clinical significance, Stage (cooking), Lymph nodes, Cervical cancer, 030219 obstetrics & reproductive medicine, Proportional hazards model, business.industry, Hazard ratio, Middle Aged, Prognosis, medicine.disease, Progression-Free Survival, Lymphovascular, medicine.anatomical_structure, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Neoplasm staging, Lymph Node Excision, Diagnostic imaging, Female, Original Article, business |
| الوصف: | PurposeLymph node metastasis (LNM) is the most significant prognostic factor in cervical cancer that was recently incorporated into the International Federation of Gynecology and Obstetrics (FIGO) staging system. This study was performed to evaluate whether the prognostic significance of LNM differs according to disease status.Materials and MethodsPatients with FIGO stage IB or higher cervical cancer who had pretreatment computed tomography and/or magnetic resonance imaging studies as well as long-term follow-up were enrolled in this retrospective study. The hazard ratio (HR) of Cox regression was used to determine the prognostic significance of LNM. The HRs were compared between the different tumor groups (based on stage, histology, tumor size, primary treatment, age, parametrium involvement, and lymphovascular space invasion).ResultsA total of 970 patients treated between January 1999 and December 2007 were included. The pretreatment LNM had prognostic significance in patients with stage IB1/IIA (HR for progression-free survival 2.10, p=0.001; HR for overall survival 1.99, p=0.005). However, the significance gradually decreased or disappeared with advancing stages. Similarly, the prognostic significance of the pretreatment LNM decreased with advancing disease status, including old age, parametrial involvement or lymphovascular space involvement. In contrast, the tumor size was associated with the prognostic significance of LNM with advancing status. The significance of the clinical LNM did not reflect the significance of the clinical stage. In contrast, the tumor size, parametrial involvement, and significance of the pathologic LNM reflected the clinical stage.ConclusionIn patients with cervical cancer, pretreatment LNM on imaging has different clinical significance depending on the tumor status. |
| تدمد: | 2005-9256 1598-2998 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44758acc101835ec129800739bd838e https://doi.org/10.4143/crt.2019.328 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b44758acc101835ec129800739bd838e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20059256 15982998 |
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