Higher levels of collagen and facilitated healing protect against ventricular rupture following myocardial infarction
| العنوان: | Higher levels of collagen and facilitated healing protect against ventricular rupture following myocardial infarction |
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| المؤلفون: | Chrishan S. Samuel, Xiao-Jun Du, Xiao-Ming Gao, Yean Leng Lim, Anthony M. Dart, Lu Fang, Yidan Su |
| المصدر: | Clinical Science. 115:99-106 |
| بيانات النشر: | Portland Press Ltd., 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Male, Genetically modified mouse, medicine.medical_specialty, Pathology, Myocardial Infarction, Heart Rupture, Mice, Transgenic, Rats, Sprague-Dawley, Mice, Species Specificity, Internal medicine, medicine, Animals, Myocardial infarction, Ventricular remodeling, Heart Rupture, Post-Infarction, Ventricular Remodeling, business.industry, Cardiac Rupture, General Medicine, medicine.disease, Rats, Enzyme Activation, Mice, Inbred C57BL, Endocrinology, medicine.anatomical_structure, Matrix Metalloproteinase 9, cardiovascular system, Matrix Metalloproteinase 2, Myocardial infarction complications, Collagen, business, Ligation, Artery |
| الوصف: | The mechanism of cardiac rupture after MI (myocardial infarction) is not fully understood. Rupture has not been reported in most laboratory species, including the rat, but does occur in mice. We have reported previously that β2-TG mice (transgenic mice with cardiac-restricted overexpression of β2-adrenergic receptors) had a lower incidence of rupture compared with NTG (non-transgenic) littermates. We hypothesized that the difference in the incidence of rupture between rodents and specific mouse strains is due to the difference in collagen content following MI. In the present study, we compared the difference in matrix remodelling post-MI between β2-TG and NTG mice and between mice and rats. MI was induced by ligation of the left main coronary artery. Following MI, tensile strength, insoluble and soluble collagen content and gelatinase expression were determined in the infarcted and non-infarcted myocardium. Better preserved tensile strength measured as TTR [tension-to-rupture; 88±14 and 58±3% of the respective sham group values for β2-TG compared with NTG mice (P |
| تدمد: | 1470-8736 0143-5221 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4536a07df1088a2733cd1393f7f293a https://doi.org/10.1042/cs20070365 |
| رقم الأكسشن: | edsair.doi.dedup.....b4536a07df1088a2733cd1393f7f293a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14708736 01435221 |
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