Correlation between Severity of Fetal Growth Restriction and Oxidative Stress in Severe Small-for-Gestational-Age Infants
| العنوان: | Correlation between Severity of Fetal Growth Restriction and Oxidative Stress in Severe Small-for-Gestational-Age Infants |
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| المؤلفون: | Shinya Abe, Mariko Ashina, Shutaro Suga, Ruka Nakasone, Asumi Yoshida, Kandai Nozu, Takumi Kido, Kenji Tanimura, Kazumichi Fujioka, Yuki Kyono |
| المصدر: | International Journal of Environmental Research and Public Health Volume 18 Issue 20 International Journal of Environmental Research and Public Health, Vol 18, Iss 10726, p 10726 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | z-score, Health, Toxicology and Mutagenesis, Birth weight, Population, Intrauterine growth restriction, Physiology, Gestational Age, Antioxidant potential, medicine.disease_cause, Article, Correlation, fetal growth restriction, small for gestational age, Fetal growth, medicine, Birth Weight, Humans, oxidative stress, education, Retrospective Studies, education.field_of_study, Fetal Growth Retardation, business.industry, Infant, Newborn, Public Health, Environmental and Occupational Health, Infant, medicine.disease, Infant, Small for Gestational Age, Small for gestational age, Medicine, Female, business, Infant, Premature, Oxidative stress |
| الوصف: | Severe small-for-gestational-age (sSGA) infants exhibit increased mortality and morbidity. Oxidative stress is suggested to be involved in intrauterine growth restriction. This retrospective study aimed to evaluate the oxidative stress level at birth in an sSGA population. Sera of 28 sSGA (sSGA group) and 31 non-sSGA (control group) infants, born at our hospital between March 2017 and March 2020, were evaluated. Oxidative stress (derivative of reactive oxidative metabolites: d-ROM level), biological antioxidant potential (BAP) level, and the ratio of d-ROM/BAP level (oxidative stress index: OSI) were measured. The sSGA group had a significantly lower birth weight (BW), BW z-score, head circumference, and height than the control group (all p < 0.05). No significant difference was noted in the BAP level sSGA infants exhibited a significantly higher d-ROM level than control infants. sSGA infants showed a significantly increased OSI compared with control infants, and the BW z-score was inversely correlated with d-ROM levels and OSI in sSGA infants (R2 = 0.300 p < 0.01 and R2 = 0.319 p = 0.02, respectively) but not in controls. In conclusion, sSGA infants, including preterm infants, exhibited higher oxidative stress at birth. The severity of fetal growth restriction was significantly correlated with oxidative stress levels at birth in sSGA infants. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1660-4601 |
| DOI: | 10.3390/ijerph182010726 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b840aaf42ae346490317b9cf188cc6 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b4b840aaf42ae346490317b9cf188cc6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16604601 |
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| DOI: | 10.3390/ijerph182010726 |