Methods for acquiring MRI data in children with autism spectrum disorder and intellectual impairment without the use of sedation
| العنوان: | Methods for acquiring MRI data in children with autism spectrum disorder and intellectual impairment without the use of sedation |
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| المؤلفون: | Audrey M. Shen, Kayla R. Harrington, Costin Tanase, Deana Li, Leonard J Abbeduto, David G. Amaral, Mark D. Shen, Laurie A. Vismara, Beth L. Goodlin-Jones, Sally J. Rogers, Melissa Mello, Christine Wu Nordahl |
| المصدر: | Journal of neurodevelopmental disorders, vol 8, iss 1 Journal of Neurodevelopmental Disorders |
| بيانات النشر: | eScholarship, University of California, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | medicine.medical_specialty, Autism, Intellectual and Developmental Disabilities (IDD), Cognitive Neuroscience, medicine.medical_treatment, Neurodevelopment, Intellectual disability, Bioengineering, Audiology, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, New Method, Clinical Research, Behavioral and Social Science, mental disorders, medicine, Psychology, 0501 psychology and cognitive sciences, Early childhood, Applied behavior analysis, Pediatric, medicine.diagnostic_test, Prevention, 05 social sciences, Neuropsychology, Neurosciences, Brain, Magnetic resonance imaging, Behavior change methods, Low-functioning autism, medicine.disease, Brain Disorders, Mental Health, Autism spectrum disorder, Pediatrics, Perinatology and Child Health, Biomedical Imaging, Neurology (clinical), 030217 neurology & neurosurgery, 050104 developmental & child psychology, Clinical psychology, Compliance, MRI |
| الوصف: | Background Magnetic resonance imaging (MRI) has been widely used in studies evaluating the neuropathology of autism spectrum disorder (ASD). Studies are often limited, however, to higher functioning individuals with ASD. MRI studies of individuals with ASD and comorbid intellectual disability (ID) are lacking, due in part to the challenges of acquiring images without the use of sedation. Methods Utilizing principles of applied behavior analysis (ABA), we developed a protocol for acquiring structural MRI scans in school-aged children with ASD and intellectual impairment. Board certified behavior analysts worked closely with each child and their parent(s), utilizing behavior change techniques such as pairing, shaping, desensitization, and positive reinforcement, through a series of mock scanner visits to prepare the child for the MRI scan. An objective, quantitative assessment of motion artifact in T1- and diffusion-weighted scans was implemented to ensure that high-quality images were acquired. Results The sample consisted of 17 children with ASD who are participants in the UC Davis Autism Phenome Project, a longitudinal MRI study aimed at evaluating brain developmental trajectories from early to middle childhood. At the time of their initial scan (2–3.5 years), all 17 children had a diagnosis of ASD and development quotient (DQ) |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d1fad6987a3bfaa0214e2c7dca232e https://escholarship.org/uc/item/5900k53d |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b4d1fad6987a3bfaa0214e2c7dca232e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |