Membrane bound GSK-3 activates Wnt signaling through disheveled and arrow
| العنوان: | Membrane bound GSK-3 activates Wnt signaling through disheveled and arrow |
|---|---|
| المؤلفون: | Anirudh Gautam Mannava, Nicholas S. Tolwinski |
| المصدر: | PLoS ONE PLoS ONE, Vol 10, Iss 4, p e0121879 (2015) |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Beta-catenin, Blotting, Western, Dishevelled Proteins, lcsh:Medicine, Fluorescent Antibody Technique, Receptors, Cell Surface, Cell membrane, Glycogen Synthase Kinase 3, medicine, Animals, Drosophila Proteins, lcsh:Science, Tissue homeostasis, beta Catenin, Adaptor Proteins, Signal Transducing, Multidisciplinary, biology, lcsh:R, Cell Membrane, Wnt signaling pathway, Signal transducing adaptor protein, Phosphoproteins, Cell biology, Wnt Proteins, Cytosol, medicine.anatomical_structure, Drosophila melanogaster, Membrane protein, biology.protein, lcsh:Q, Female, Signal transduction, Signal Transduction, Research Article |
| الوصف: | Wnt ligands and their downstream pathway components coordinate many developmental and cellular processes. In adults, they regulate tissue homeostasis through regulation of stem cells. Mechanistically, signal transduction through this pathway is complicated by pathway components having both positive and negative roles in signal propagation. Here we examine the positive role of GSK-3/Zw3 in promoting signal transduction at the plasma membrane. We find that targeting GSK-3 to the plasma membrane activates signaling in Drosophila embryos. This activation requires the presence of the co-receptor Arrow-LRP5/6 and the pathway activating protein Disheveled. Our results provide genetic evidence for evolutionarily conserved, separable roles for GSK-3 at the membrane and in the cytosol, and are consistent with a model where the complex cycles from cytosol to membrane in order to promote signaling at the membrane and to prevent it in the cytosol. |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e9f4e6b62efbbf6d9eb0d79ff1969d https://pubmed.ncbi.nlm.nih.gov/25848770 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b4e9f4e6b62efbbf6d9eb0d79ff1969d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
|---|