Adipose‐specific inactivation of thyroid stimulating hormone receptors in mice modifies body weight, temperature and gene expression in adipocytes
| العنوان: | Adipose‐specific inactivation of thyroid stimulating hormone receptors in mice modifies body weight, temperature and gene expression in adipocytes |
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| المؤلفون: | Claude Marcus, Ingrid Dahlman, Veroniqa Lundbäck, Agné Kulyté |
| المصدر: | Physiological Reports Physiological Reports, Vol 8, Iss 16, Pp n/a-n/a (2020) |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Physiology, WAT, Adipose tissue, Adipokine, White adipose tissue, 030204 cardiovascular system & hematology, Biology, Weight Gain, lcsh:Physiology, Body Temperature, adipogenesis, Mice, 03 medical and health sciences, 0302 clinical medicine, Thyroid-stimulating hormone, Physiology (medical), Internal medicine, Adipocytes, medicine, Animals, adipose‐specific knockout, Receptor, Cells, Cultured, Original Research, lcsh:QP1-981, Body Weight, BAT, Receptors, Thyrotropin, thermogenesis, TSHR, Thermogenin, Mice, Inbred C57BL, Endocrinology, Adipogenesis, uncoupling protein‐1, Transcriptome, Thermogenesis, Gene Deletion, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery |
| الوصف: | Background In obesity, the expression level of thyroid stimulating hormone receptor in adipose tissue is reduced and the levels of thyroid stimulating hormone (TSH) are often elevated within the normal range. Purpose/Aim To investigate the role of TSHR in brown and white adipose tissue (AT) using TSHR knockout (KO) mice and the physiological phenotypes affected by the TSHR knockout. Methods AT‐specific TSHR KO male mice and wild type (WT) controls were given a high‐fat diet (HFD) or a control diet (CD). Body weights and food consumption were recorded for 20 weeks and body temperatures for the first 3 weeks. At termination, white and brown adipocytes were isolated. Gene expressios was investigated using real‐time PCR. In a subgroup of female KO mice, glucose tolerance was investigated. Results TSHR were partially knocked out in KO mice, which gained more weight than WT mice when fed both a CD (p = .03) and HFD (p = .003). Body temperatures were lower in KO mice on CD (p TSHR in adipose tissue appears to be important in regulating body composition in mice, separately from the effects of circulating thyroid hormone levels. A partial deletion of TSHR in adipocytes results in an increased body weight and an altered adipocyte‐specific gene expression in brown and white adipocytes. |
| تدمد: | 2051-817X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f111aa344c6600edf1b4ebbc550b80 https://doi.org/10.14814/phy2.14538 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b4f111aa344c6600edf1b4ebbc550b80 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2051817X |
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