Plasma fetal bile acids 7α-hydroxy-3-oxochol-4-en-24-oic acid and 3-oxachola-4,6-dien-24-oic acid indicate severity of liver cirrhosis
| العنوان: | Plasma fetal bile acids 7α-hydroxy-3-oxochol-4-en-24-oic acid and 3-oxachola-4,6-dien-24-oic acid indicate severity of liver cirrhosis |
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| المؤلفون: | Dong Wook Kang, Billy J. Molloy, Zeno Spârchez, Diren Beyoğlu, Jeffrey R. Idle, Hyeonho Jeon, Tudor Mocan |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Liver Cirrhosis, Male, 0301 basic medicine, medicine.medical_specialty, Taurine, Carcinoma, Hepatocellular, Cirrhosis, genetic structures, Science, Severity of Illness Index, behavioral disciplines and activities, Gastroenterology, Article, Bile Acids and Salts, 03 medical and health sciences, Liver disease, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Humans, Aged, Aged, 80 and over, Fetus, Multidisciplinary, Chemistry, Liver Neoplasms, Middle Aged, medicine.disease, 030104 developmental biology, nervous system, Inborn error of metabolism, Hepatocellular carcinoma, Glycine, Medicine, 3-oxochol-4-en-24-oic acid, Female, 030211 gastroenterology & hepatology, Oxidoreductases, Biomarkers, psychological phenomena and processes |
| الوصف: | Two 3-oxo-Δ4 fetal bile acids, 3-oxachola-4,6-dien-24-oic acid (1) and 7α-hydroxy-3-oxochol-4-en-24-oic acid (2), occur normally in the human fetus but remain elevated in neonates and children with severe cholestatic liver disease due to an autosomal recessive inborn error of metabolism affecting Δ4-3-oxo-steroid 5β-reductase (AKR1D1). Relatively little is known about 1 and 2 in adult patients with liver disease. The chemical synthesis of 1 and 2 is therefore described and their quantitation in plasma by ultrarapid chromatography-triple quadrupole mass spectrometry. Plasma concentrations of 1 and 2 were investigated in 25 adult patients with varying degrees of liver cirrhosis with and without hepatocellular carcinoma (HCC). Highly statistically significant correlations (P 1 and 2 concentrations, both alone and combined. The presence of HCC did not influence these correlations. Plasma cholic, chenodeoxycholic, deoxycholic, lithocholic or ursodeoxycholic acids, free and as their glycine or taurine conjugates, did not correlate with Child–Pugh or MELD score when corrected for multiple comparisons. These findings demonstrate that plasma levels of fetal bile acids 3-oxachola-4,6-dien-24-oic acid and 7α-hydroxy-3-oxochol-4-en-24-oic acid and likely deteriorating AKR1D1 activity indicate the severity of liver cirrhosis measured by the Child–Pugh and MELD scores. |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f12af075f1c680a15034049e7bfc93 https://doi.org/10.1038/s41598-021-87921-5 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b4f12af075f1c680a15034049e7bfc93 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20452322 |
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