A Retrospective Descriptive Analysis of Patient Adherence to Dabigatran at a Large Academic Medical Center
| العنوان: | A Retrospective Descriptive Analysis of Patient Adherence to Dabigatran at a Large Academic Medical Center |
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| المؤلفون: | Tiffany K. Pon, Alan Chuang, Timothy W. Cutler, Jennifer M Branch, Tony D. Huynh, Robert G. Witt, Richard H. White |
| المصدر: | Journal of Managed Care Pharmacy. 20:1028-1034 |
| بيانات النشر: | Academy of Managed Care Pharmacy, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Pharmaceutical Science, Pharmacy, Antithrombins, Medication Adherence, Dabigatran, Thromboembolism, Internal medicine, Humans, Medicine, Medical prescription, Intensive care medicine, Aged, Retrospective Studies, Aged, 80 and over, Academic Medical Centers, Descriptive statistics, business.industry, Health Policy, Primary care physician, Retrospective cohort study, Middle Aged, Hospitalization, Clinical trial, beta-Alanine, Population study, Benzimidazoles, Female, business, medicine.drug |
| الوصف: | BACKGROUND: Clinical trials evaluating the efficacy of dabigatran followed a very strict protocol, which included close monitoring and follow-up. Patients followed in this controlled environment had an average medication possession ratio (MPR) > 0.95. However, very few studies have evaluated patient adherence to dabigatran in a real-world setting. Other studies of chronic medications indicate patients are not reliably adherent to twice daily regimens. Adherence to therapy is particularly important for direct thrombin inhibitors because there may be a risk of increased thromboembolic events associated with poor adherence to these agents. OBJECTIVE: To identify the MPR for patients prescribed dabigatran at a large academic medical center and affiliated clinics. METHODS: This retrospective descriptive study evaluated the MPR for patients prescribed dabigatran between January 1, 2012, and December 31, 2012. Patients included in this study had to receive dabigatran for a minimum of 3 months, have a primary care physician or cardiologist at the medical center or affiliated clinics, and must not use a mail order pharmacy. Patient MPR was calculated based on prescriptions picked up from the patient. RESULTS: After screening 400 patients, 159 patients met eligibility criteria. The mean MPR for the patients in this study was 0.63. Overall, 43% of the patients had an MPR of < 0.80, and the mean MPR for this subgroup was 0.39 ± 0.27; 57% of the study population had an MPR of 0.80 or higher, with a mean MPR of 0.94 ± 0.08. There was a significantly higher proportion of men (67.7%, P = 0.0112) and a larger number of “as needed medications” prescribed (1.73 vs. 0.86, P = 0.0039) in patients with an MPR < 0.80. There were 5 patients hospitalized during the study period (3 for bleeding, 1 for confusion, and 1 death not related to dabigatran therapy). CONCLUSIONS: The relatively low mean MPR seen in this study may indicate that there is a need for improved anticoagulation services and followup for patients taking dabigatran. |
| تدمد: | 1944-706X 1083-4087 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53765f5b442052ec2bf045dd4dd205a https://doi.org/10.18553/jmcp.2014.20.10.1028 |
| رقم الأكسشن: | edsair.doi.dedup.....b53765f5b442052ec2bf045dd4dd205a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1944706X 10834087 |
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