The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer
| العنوان: | The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer |
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| المؤلفون: | Elias Castanas, George Notas, Andreas Tsapis, Marilena Kampa, Efstathios N. Stathopoulos |
| المصدر: | Frontiers in Oncology Frontiers in Oncology, Vol 10 (2020) |
| بيانات النشر: | Frontiers Media S.A., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, APRIL (TNFSF13), lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, breast cancer, medicine, B-cell activating factor, Receptor, BAFF receptor, TACI (TNFRSF13B), Multiple myeloma, computer.programming_language, BCMA (TNFRSF17), Caml, business.industry, B-Cell Maturation Antigen, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Perspective, Cancer research, BAFF (TNFSF13B), Tumor necrosis factor alpha, BAFFR (TNFRSF13C), business, computer |
| الوصف: | Tumor necrosis factor (TNF) superfamily consists of 19 ligands and 29 receptors and is related to multiple cellular events from proliferation and differentiation to apoptosis and tumor reduction. In this review, we overview the whole system, and we focus on A proliferation-inducing ligand (APRIL, TNFSF13) and B cell-activating factor (BAFF, TNFSF13B) and their receptors transmembrane activator and Ca2+ modulator (CAML) interactor (TACI, TNFRSF13B), B cell maturation antigen (BCMA, TNFRSF17), and BAFF receptor (BAFFR, TNFRSF13C). We explore their role in cancer and novel biological therapies introduced for multiple myeloma and further focus on breast cancer, in which the modulation of this system seems to be of potential interest, as a novel therapeutic target. Finally, we discuss some precautions which should be taken into consideration, while targeting the APRIL–BAFF system. |
| اللغة: | English |
| تدمد: | 2234-943X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54fdb3e2ada50ef47ed8991727ded79 http://europepmc.org/articles/PMC7308424 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b54fdb3e2ada50ef47ed8991727ded79 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2234943X |
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