Development of immediate release Rupatadine fumarate 10 mg tablets: A Quality by Design (QbD) approach
| العنوان: | Development of immediate release Rupatadine fumarate 10 mg tablets: A Quality by Design (QbD) approach |
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| المؤلفون: | Gustavo Carazo Berrocal, Rolando Vargas Zúñiga, Eleaneth Baltodano Viales, Briner Calvo Guzmán, Luis Castillo Henríquez, German Madrigal Redondo |
| المصدر: | Drug Development and Industrial Pharmacy, vol. 45(10), pp.1674-1681 Kérwá Universidad de Costa Rica instacron:UCR |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Computer science, Chemistry, Pharmaceutical, Drug Compounding, Rupatadine, Cyproheptadine, Direct compression, Immediate release, Pharmaceutical Science, Lactose, 02 engineering and technology, Antihistaminic, 030226 pharmacology & pharmacy, Quality by Design, Excipients, 03 medical and health sciences, 0302 clinical medicine, Fumarates, Drug Discovery, medicine, Technology, Pharmaceutical, Cellulose, Rupatadine fumarate, Pharmacology, Organic Chemistry, Starch, 021001 nanoscience & nanotechnology, Solubility, Formulation, Pharmaceutical Research and Development, Carboxymethylcellulose Sodium, 0210 nano-technology, Stearic Acids, Tablets, Biomedical engineering, medicine.drug |
| الوصف: | The main objective of this research is to develop an immediate release Rupatadine fumarate 10 mg tablets formulation by direct compression, through a Quality by Design approach in Costa Rica. Methods: According to a Quality by Design approach; Target Product Profile, Quality Target Product Profile and the Critical Quality Attributes were defined. In the preformulation study, compatibility tests were carried out between the raw materials. The Critical Material Attributes were established using Quality Risk Management. Three formulation prototypes were prepared by direct compression and its Critical Process Parameters were defined. The analysis of the prototypes was realized in terms of organoleptic properties, identification, potency, content uniformity, dissolution, disintegration, friability and loss by drying. Results: All the prototypes showed a white or slightly pink surface, potency between 90.0 – 110.0% of the labeling, an acceptance value for the content uniformity lower than the specification (AV < 15), the dissolved amount of active pharmaceutical ingredient was greater than 85.0 % at 30 minutes, friability less than 1.0 %, a disintegration time less than 15 minutes and moisture content less than 2.0%. Conclusions: The approaching of a Quality by Design model to the current development allowed to obtain satisfactory results in the three formulation prototypes. The excipients to be used can be lactose monohydrate, microcrystalline cellulose, sodium croscarmellose, pregelatinized starch, magnesium stearate, stearic acid and PVP K-30. Universidad de Costa Rica/[]/UCR/Costa Rica UCR::Vicerrectoría de Docencia::Salud::Facultad de Farmacia UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR) |
| تدمد: | 1520-5762 0363-9045 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b552c90aaf36523c16b0c4bf3ae50397 https://doi.org/10.1080/03639045.2019.1652637 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b552c90aaf36523c16b0c4bf3ae50397 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15205762 03639045 |
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