التفاصيل البيبلوغرافية
العنوان:
The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate
المؤلفون:
Lee Andrew Harrison , Michael Dennis Dowle , Harry Finch , Robin Andrew Smith , Pritom Shah , K.Abhhilash Kumar , Gill Fleetwood , Simon Teanby Hodgson , George W. Hardy , Graham Murkitt , Simon J. F. Macdonald , Graham G. A. Inglis , Christopher R Molloy , Geoffrey D. Clarke , Augustin Amour , Rosalind E Godward , Tony Padfield , Davina Humphreys , M. R. Johnson , Mary Dixon , Tadeusz Skarzynski , Onkar M. P. Singh
المصدر:
Bioorganic & Medicinal Chemistry Letters . 11:895-898
بيانات النشر:
Elsevier BV, 2001.
سنة النشر:
2001
مصطلحات موضوعية:
Lactams , Human neutrophil , Metabolic Clearance Rate , Clinical Biochemistry , Administration, Oral , Biological Availability , Pharmaceutical Science , Pharmacology , Biochemistry , Dogs , Drug Stability , Piperidines , Pharmacokinetics , Cricetinae , Drug Discovery , Animals , Molecular Biology , Short duration , Serpins , Bacteria , Pancreatic Elastase , Chemistry , Serine Endopeptidases , Organic Chemistry , Elastase , Bacterial Infections , Rats , Bioavailability , Orally active , Pharmacodynamics , Molecular Medicine , Crystallization , Leukocyte Elastase , Intracellular
الوصف:
The discovery of a potent intracellular inhibitor of human neutrophil elastase which is orally active and has a long duration of action is described. The pharmacodynamic and pharmacokinetic properties of a trans-lactam development candidate, GW311616A, are described.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b569e3c9519903b411ede0c093223361 https://doi.org/10.1016/s0960-894x (01)00078-6
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....b569e3c9519903b411ede0c093223361
قاعدة البيانات:
OpenAIRE
