IFNL3 genotype is associated with pulmonary fibrosis in patients with systemic sclerosis
| العنوان: | IFNL3 genotype is associated with pulmonary fibrosis in patients with systemic sclerosis |
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| المؤلفون: | Gene-Siew Ngian, Ali Bayoumi, Khaled Thabet, Lorenzo Beretta, Wendy Stevens, Nicholas Manolios, Kathleen Tymms, Susanna Proudman, Jane Zochling, Jacob George, Janet Roddy, Maureen Rischmueller, Mayada Metwally, Gemma Strickland, Susan C. Lester, Olfat G. Shaker, Pravin Hissaria, Mohammed Eslam, Mandana Nikpour, Christopher Liddle, Joanne Sahhar, Jennifer G Walker |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-5 (2019) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Liver Cirrhosis, Male, 0301 basic medicine, medicine.medical_specialty, Pulmonary Fibrosis, lcsh:Medicine, Inflammation, Genome-wide association study, Disease, Polymorphism, Single Nucleotide, Gastroenterology, Article, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, Internal medicine, Genetics research, Pulmonary fibrosis, Genotype, medicine, Humans, Genetic Predisposition to Disease, lcsh:Science, Aged, Skin, Scleroderma, Systemic, Multidisciplinary, integumentary system, business.industry, lcsh:R, Translational research, Middle Aged, medicine.disease, Pathophysiology, 3. Good health, 030104 developmental biology, Etiology, Female, 030211 gastroenterology & hepatology, lcsh:Q, Interferons, medicine.symptom, business |
| الوصف: | Fibrosis across different organs and tissues is likely to share common pathophysiological mechanisms and pathways. Recently, a polymorphism (rs12979860) near the interferon lambda gene (IFNL3) was shown to be associated with fibrosis in liver across multiple disease etiologies. We determined whether this variant is a risk factor for pulmonary fibrosis (PF) and worsening cutaneous fibrosis in systemic sclerosis (SSc). Caucasian patients with SSc (n = 733) were genotyped to test for association with the presence of PF and worsening of skin fibrosis. Serum IFN-λ3 levels from 200 SSc cases were evaluated. An association of the IFNL3 polymorphism with PF was demonstrated (OR: 1.66 (95% CI: 1.142–2.416, p = 0.008). The IFNL3 variant was not a risk factor for worsening of skin fibrosis. Functionally, IFN-λ3 serum levels were higher among subjects with PF compared to those unaffected (P |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b587700ef2a754265d27741002f3b71b http://link.springer.com/article/10.1038/s41598-019-50709-9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b587700ef2a754265d27741002f3b71b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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