Atorvastatin Increases the Expression of Long Non-Coding RNAs ARSR and CHROME in Hypercholesterolemic Patients: A Pilot Study
| العنوان: | Atorvastatin Increases the Expression of Long Non-Coding RNAs ARSR and CHROME in Hypercholesterolemic Patients: A Pilot Study |
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| المؤلفون: | Yalena Prado, Carmen Gloria Ubilla, Isis Paez, Tomás Zambrano, Luis A. Salazar |
| المصدر: | Pharmaceuticals, Vol 13, Iss 382, p 382 (2020) Pharmaceuticals Volume 13 Issue 11 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Drug, Statin, medicine.drug_class, Atorvastatin, media_common.quotation_subject, lncRNAs, Pharmaceutical Science, lcsh:Medicine, lcsh:RS1-441, Single-nucleotide polymorphism, CHROME, 030204 cardiovascular system & hematology, Pharmacology, urologic and male genital diseases, Article, lcsh:Pharmacy and materia medica, 03 medical and health sciences, 0302 clinical medicine, Renal cell carcinoma, Drug Discovery, medicine, epidrugs, Gene, media_common, hypercholesterolemia, medicine.diagnostic_test, business.industry, Sunitinib, lcsh:R, nutritional and metabolic diseases, ARSR, atorvastatin, medicine.disease, 030104 developmental biology, Molecular Medicine, lipids (amino acids, peptides, and proteins), LASER, Lipid profile, business, medicine.drug |
| الوصف: | Atorvastatin is extensively used to treat hypercholesterolemia. However, the wide interindividual variability observed in response to this drug still needs further elucidation. Nowadays, the biology of long non-coding RNAs (lncRNAs) is better understood, and some of these molecules have been related to cholesterol metabolism. Therefore, they could provide additional information on variability in response to statins. The objective of this research was to evaluate the effect of atorvastatin on three lncRNAs (lncRNA ARSR: Activated in renal cell carcinoma (RCC) with sunitinib resistance, ENST00000424980 lncRNA LASER: lipid associated single nucleotide polymorphism locus, ENSG00000237937 and lncRNA CHROME: cholesterol homeostasis regulator of miRNA expression, ENSG00000223960) associated with genes involved in cholesterol metabolism as predictors of lipid-lowering therapy performance. Twenty hypercholesterolemic patients were treated for four weeks with atorvastatin (20 mg/day). The lipid profile was determined before and after drug administration using conventional assays. The expression of lncRNAs was assessed in peripheral blood samples by RT-qPCR. As expected, atorvastatin improved the lipid profile, decreasing total cholesterol, LDL-C, and the TC/HDL-C ratio (p < 0.0001) while increasing the expression of lncRNAs ARSR and CHROME (p < 0.0001) upon completion of treatment. LASER did not show significant differences among the groups (p = 0.50). Our results indicate that atorvastatin modulates the expression of cholesterol-related lncRNAs differentially, suggesting that these molecules play a role in the variability of response to this drug however, additional studies are needed to disclose the implication of this differential regulation on statin response. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1424-8247 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ce55c1e1ab76dea2bdd5c6ee5e4fa2 https://www.mdpi.com/1424-8247/13/11/382 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b5ce55c1e1ab76dea2bdd5c6ee5e4fa2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14248247 |
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