A high-affinity cocaine binding site associated with the brain acid soluble protein 1
| العنوان: | A high-affinity cocaine binding site associated with the brain acid soluble protein 1 |
|---|---|
| المؤلفون: | Maged M. Harraz, Adarsha P. Malla, Evan R. Semenza, Maria Shishikura, Manisha Singh, Yun Hwang, In Guk Kang, Young Jun Song, Adele M. Snowman, Pedro Cortés, Senthilkumar S. Karuppagounder, Ted M. Dawson, Valina L. Dawson, Solomon H. Snyder |
| المصدر: | Proceedings of the National Academy of Sciences. 119 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Dopamine Plasma Membrane Transport Proteins, Binding Sites, Multidisciplinary, Dopamine, Receptors, Drug, Nerve Tissue Proteins, Corpus Striatum, Rats, Cytoskeletal Proteins, Mice, Cocaine, Animals, Humans, Calmodulin-Binding Proteins, Gene Knock-In Techniques, Carrier Proteins |
| الوصف: | Significance Cocaine is a monoamine transport inhibitor. Current models attributing pharmacologic actions of cocaine to inhibiting the activity of the amine transporters alone failed to translate to the clinic. Cocaine inhibition of the dopamine, serotonin, and norepinephrine transporters is relatively weak, suggesting that blockade of the amine transporters alone cannot account for the actions of cocaine, especially at low doses. There is evidence for significantly more potent actions of cocaine, suggesting the existence of a high-affinity receptor(s) for the drug. Identifying and characterizing such receptors will deepen our understanding of cocaine pharmacologic actions and pave the way for therapeutic development. Here we identify a high-affinity cocaine binding site associated with BASP1 that is involved in mediating the drug’s psychotropic actions. |
| تدمد: | 1091-6490 0027-8424 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fe02ba05d540959d3a5dc2d47bac82 https://doi.org/10.1073/pnas.2200545119 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b5fe02ba05d540959d3a5dc2d47bac82 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
|---|