Iron deposition in cranial bone marrow with sickle cell disease: MR assessment using a fat suppression technique
| العنوان: | Iron deposition in cranial bone marrow with sickle cell disease: MR assessment using a fat suppression technique |
|---|---|
| المؤلفون: | J. H. Humbert, M. S. Kogutt, K. Kaneko, A. E. Robinson |
| المصدر: | Pediatric Radiology. 23:435-438 |
| بيانات النشر: | Springer Science and Business Media LLC, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Adolescent, Iron, Anemia, Sickle Cell, Bone Marrow, medicine, Humans, Radiology, Nuclear Medicine and imaging, Child, Hyperplasia, medicine.diagnostic_test, business.industry, Skull, Ultrasound, Infant, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Sickle cell anemia, Hemoglobinopathy, medicine.anatomical_structure, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, Transfusion therapy, Bone marrow, Erythrocyte Transfusion, Complication, Nuclear medicine, business |
| الوصف: | Thirteen patients with sickle cell disease (SCD) undergoing transfusion therapy and 8 control patients were examined by magnetic resonance imaging to discriminate bone marrow change due to iron deposition from hematologic marrow hyperplasia. Using T1-weighted spin echo images, only two subjects showed extremely low signal intensity marrow compatible with iron deposition. However, using T2-weighted fast spin echo images with fat suppression, cranial bone marrow in SCD patients with transfusion therapy showed considerably lower signal than that of controls. The main cause of marrow signal decrease in SCD patients with transfusion therapy was considered to be iron deposition due to repeated transfusion therapy rather than red marrow hyperplasia. |
| تدمد: | 1432-1998 0301-0449 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63c0f2a60c548f0e1ee9768fee85acb https://doi.org/10.1007/bf02012442 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....b63c0f2a60c548f0e1ee9768fee85acb |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321998 03010449 |
|---|