Blood pressure, T cells, and mortality in people with HIV in Tanzania during the first 2 years of antiretroviral therapy
| العنوان: | Blood pressure, T cells, and mortality in people with HIV in Tanzania during the first 2 years of antiretroviral therapy |
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| المؤلفون: | Robert N. Peck, Christina Myalla, Annet Kirabo, Justin R Kingery, Bernard Desderius, Saidi Kapiga, Myung Hee Lee, Karl Reis, Abel Makubi |
| المصدر: | J Clin Hypertens (Greenwich) |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Tuberculosis, T-Lymphocytes, Endocrinology, Diabetes and Metabolism, Human immunodeficiency virus (HIV), Blood Pressure, HIV Infections, Disease, 030204 cardiovascular system & hematology, medicine.disease_cause, Tanzania, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Internal Medicine, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, biology, business.industry, HIV, medicine.disease, biology.organism_classification, Antiretroviral therapy, Occult, CD4 Lymphocyte Count, Blood pressure, Hypertension, Female, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Cardiovascular disease is now a leading cause of mortality in people with HIV (PWH). High blood pressure is the major driver of cardiovascular disease. Despite this, little is known about blood pressure in PWH during the early years of antiretroviral therapy (ART). In this prospective cohort study in Tanzania, the authors conducted unobserved blood pressure measurements at enrollment, 3, 6, 12, 18, and 24 months in 500 PWH initiating ART and 504 HIV-uninfected adults. The authors excluded measurements taken on antihypertensive medications. Although PWH had a significantly lower blood pressure before ART initiation, they had a significantly greater increase in blood pressure during the first 2 years of ART compared to HIV-uninfected controls. Blood pressure correlates in PWH differed from HIV-uninfected controls. In PWH, lower baseline CD4+ T-cell counts were associated with lower blood pressure, and greater increases in CD4+ T-cell counts on ART were associated with greater increases in blood pressure, both on average and within individuals. In addition, PWH with a systolic blood pressure (SBP) |
| تدمد: | 1751-7176 1524-6175 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ebddd472403b2300366b498441de09 https://doi.org/10.1111/jch.13975 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b6ebddd472403b2300366b498441de09 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17517176 15246175 |
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