أعرض في EDS

Hsp90 restrains ErbB‐2/HER2 signalling by limiting heterodimer formation

التفاصيل البيبلوغرافية
العنوان: Hsp90 restrains ErbB‐2/HER2 signalling by limiting heterodimer formation
المؤلفون: Ami Citri, Yosef Yarden, Judith Gan, János Szöllosi, Yaron Mosesson, Gyorgi Vereb
المصدر: EMBO reports. 5:1165-1170
بيانات النشر: EMBO, 2004.
سنة النشر: 2004
مصطلحات موضوعية: animal structures, Receptor, ErbB-2, Amino Acid Motifs, Molecular Sequence Data, Scientific Report, Biology, Biochemistry, Growth factor receptor, ErbB, Genetics, Amino Acid Sequence, HSP90 Heat-Shock Proteins, skin and connective tissue diseases, Receptor, neoplasms, Molecular Biology, Hsp90, Cell biology, Signalling, Protein kinase domain, Cancer research, biology.protein, Signal transduction, Dimerization, Tyrosine kinase, Signal Transduction
الوصف: ErbB-2/HER2 is an oncogenic tyrosine kinase that regulates a signalling network by forming ligand-induced heterodimers with several growth factor receptors of the ErbB family. Hsp90 and co-chaperones regulate degradation of ErbB-2 but not other ErbB members. Here, we report that the role of Hsp90 in modulating the ErbB network extends beyond regulation of protein stability. The capacity of ErbB-2 to recruit ligand-bound receptors into active heterodimers is limited by Hsp90, which is dissociated from ErbB-2 following ligand-induced heterodimerization. We show that Hsp90 binds a specific loop within the kinase domain of ErbB-2, thereby restraining heterodimer formation and catalytic function. These results define a role for Hsp90 as a molecular switch regulating the ErbB signalling network by limiting formation of ErbB-2-centred receptor complexes.
تدمد: 1469-3178
1469-221X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7072345663f17142072b818398525b1
https://doi.org/10.1038/sj.embor.7400300
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....b7072345663f17142072b818398525b1
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14693178
1469221X