Primary cilium: a paradigm for integrating mathematical modeling with experiments and numerical simulations in mechanobiology
| العنوان: | Primary cilium: a paradigm for integrating mathematical modeling with experiments and numerical simulations in mechanobiology |
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| المؤلفون: | Zhangli Peng, Andrew Resnick, Yuan-Nan Young |
| المصدر: | Mathematical Biosciences and Engineering, Vol 18, Iss 2, Pp 1214-1237 (2021) Mathematical biosciences and engineering : MBE |
| بيانات النشر: | AIMS Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | cilium, lcsh:Biotechnology, Biophysics, Mitosis, 02 engineering and technology, elastohydrodynamics, Microtubules, Article, Mechanobiology, slender-body, Chemical stimuli, Microtubule, lcsh:TP248.13-248.65, 0502 economics and business, 0202 electrical engineering, electronic engineering, information engineering, Cilia, fluid-structure interactions, Physics, Mathematical model, Applied Mathematics, Cilium, lcsh:Mathematics, 05 social sciences, General Medicine, Models, Theoretical, lcsh:QA1-939, Mitotic cycle, Computational Mathematics, Modeling and Simulation, 020201 artificial intelligence & image processing, mechanosensing, Interaction problem, Mother centriole, General Agricultural and Biological Sciences, Neuroscience, 050203 business & management |
| الوصف: | Primary cilia are non-motile, solitary (one per cell) microtubule-based organelles that emerge from the mother centriole after cells have exited the mitotic cycle. Identified as a mechanosensing organelle that responds to both mechanical and chemical stimuli, the primary cilium provides a fertile ground for integrative investigations of mathematical modeling, numerical simulations, and experiments. Recent experimental findings revealed considerable complexity to the underlying mechanosensory mechanisms that transmit extracellular stimuli to intracellular signaling many of which include primary cilia. In this invited review, we provide a brief survey of experimental findings on primary cilia and how these results lead to various mathematical models of the mechanics of the primary cilium bent under an external forcing such as a fluid flow or a trap. Mathematical modeling of the primary cilium as a fluid-structure interaction problem highlights the importance of basal anchorage and the anisotropic moduli of the microtubules. As theoretical modeling and numerical simulations progress, along with improved state-of-the-art experiments on primary cilia, we hope that details of ciliary regulated mechano-chemical signaling dynamics in cellular physiology will be understood in the near future. |
| اللغة: | English |
| تدمد: | 1551-0018 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7389f16c8a942ddd39be36448424929 http://www.aimspress.com/article/doi/10.3934/mbe.2021066?viewType=HTML |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b7389f16c8a942ddd39be36448424929 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15510018 |
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