Unexpected skin lesions secondary to metastasis of urothelial carcinoma
| العنوان: | Unexpected skin lesions secondary to metastasis of urothelial carcinoma |
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| المؤلفون: | Yassine Ouanes, Yassine Nouira, S. Zaghbib, Ahmed Sellami, Zinet Ghorbel, Sami Ben Rhouma, Ines Chelly, T. Taktak, H. Boussaffa |
| المصدر: | International Journal of Surgery Case Reports |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, medicine.medical_treatment, Rectum, Article, Metastasis, Urothelial bladder carcinoma, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Carcinoma, Medicine, Chemotherapy, integumentary system, medicine.diagnostic_test, business.industry, medicine.disease, Transitional cell carcinoma, Lymphatic system, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Skin biopsy, Immunohistochemistry, 030211 gastroenterology & hepatology, Surgery, Skin metastasis, business |
| الوصف: | Highlights • Skin metastases of urothelial bladder carcinoma are rare. • The inflammatory presentation, as seen in our case, is exceptional. • Diagnosis requires immunohistochemical study of a skin biopsy. • The prognosis after the appearance of cutaneous metastasis is poor. Introduction Metastatic spread of urothelial bladder carcinoma (UBC) rarely involves the skin which is associated with a poor prognosis. We present a rare case of UBC with cutaneous metastases which is exceptional by its inflammatory clinical form. Presentation of case A 62-year-old male was diagnosed with a non-metastatic muscle invasive transitional cell bladder carcinoma invading the anterior wall of the rectum. Cisplatin-based chemotherapy was indicated but refused by the patient. Three months later, he developed cutaneous lesions in the left axilla and the right inguinal fold. These lesions were budding, nodular and inflammatory corresponding to carcinomatous metastasis on skin biopsy which urothelial origin was confirmed by immunohistochemical analysis. The patient died four weeks later after multi-organ failure. Discussion Skin metastasis of transitional cell carcinoma of the bladder are uncommon, representing 0.84% of all cutaneous metastases. The inflammatory presentation, as seen in our case, is rarer than the other types and is usually due to a lymphatic extension. The clinical appearance of cutaneous metastases might mimic other common dermatologic disorders; Thus, diagnosis requires histological confirmation by microscopic examination and immunohistochemical study of a skin biopsy. The prognosis after the appearance of cutaneous metastases is generally poor with a median disease-specific survival of less than 12 months Treatment is palliative and is principally based on chemotherapy, analgesics and psychological support. Conclusion Cutaneous metastases secondary to urothelial bladder carcinoma are exceptional especially in its inflammatory presentation. Diagnosis is based on immunohistochemical study. Treatment is based on chemotherapy and the prognosis is poor. |
| تدمد: | 2210-2612 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b794d89594c9f35347d1351aeb217d8d https://doi.org/10.1016/j.ijscr.2019.10.007 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b794d89594c9f35347d1351aeb217d8d |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 22102612 |
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