Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1
| العنوان: | Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1 |
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| المؤلفون: | Teresa Liu, Chia-Yun Lo, Zhiping Ye, Terrence M. Tumpey, Stephen Mark Tompkins, Julia A. Misplon, Suzanne L. Epstein, Zi-Shan Zhao, Robert J. Hogan, Kimberly A Benton, Zhengqi Wu |
| المصدر: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 13, Iss 3, Pp 426-426 (2007) |
| بيانات النشر: | Centers for Disease Control and Prevention (CDC), 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | influenza A virus H1N1 subtype, Genes, Viral, Epidemiology, T-Lymphocytes, Drug Evaluation, Preclinical, lcsh:Medicine, Antibodies, Viral, medicine.disease_cause, Ion Channels, Mice, Vaccines, DNA, Influenza A virus, Mice, Inbred BALB C, Vaccines, Synthetic, Vaccination, virus diseases, Recombinant Proteins, Infectious Diseases, Influenza Vaccines, Female, Injections, Intraperitoneal, Microbiology (medical), Genetic Vectors, Molecular Sequence Data, Cross Reactions, Biology, Injections, Intramuscular, H5N1 genetic structure, Antigenic drift, Adenoviridae, DNA vaccines, lcsh:Infectious and parasitic diseases, DNA vaccination, Viral Matrix Proteins, Orthomyxoviridae Infections, Antigen, medicine, Animals, lcsh:RC109-216, Amino Acid Sequence, M2 protein, Immunization Schedule, research, Viral matrix protein, Influenza A Virus, H5N1 Subtype, lcsh:R, Virology, Influenza A virus subtype H5N1, influenza A virus H5N1 subtype, Immunology, Sequence Alignment, influenza A virus H3N2 subtype |
| الوصف: | Vaccination of mice with influenza matrix protein 2 induced cross-reactive antibody responses. Changes in influenza viruses require regular reformulation of strain-specific influenza vaccines. Vaccines based on conserved antigens provide broader protection. Influenza matrix protein 2 (M2) is highly conserved across influenza A subtypes. To evaluate its efficacy as a vaccine candidate, we vaccinated mice with M2 peptide of a widely shared consensus sequence. This vaccination induced antibodies that cross-reacted with divergent M2 peptide from an H5N1 subtype. A DNA vaccine expressing full-length consensus-sequence M2 (M2-DNA) induced M2-specific antibody responses and protected against challenge with lethal influenza. Mice primed with M2-DNA and then boosted with recombinant adenovirus expressing M2 (M2-Ad) had enhanced antibody responses that cross-reacted with human and avian M2 sequences and induced T-cell responses. This M2 prime-boost vaccination conferred broad protection against challenge with lethal influenza A, including an H5N1 strain. Vaccination with M2, with key sequences represented, may provide broad protection against influenza A. |
| تدمد: | 1080-6059 1080-6040 |
| DOI: | 10.3201/eid1303.061125 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c82e8b9dc5cc998eb7f2e22c906c9e |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b7c82e8b9dc5cc998eb7f2e22c906c9e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10806059 10806040 |
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| DOI: | 10.3201/eid1303.061125 |