التفاصيل البيبلوغرافية
العنوان:
Myocytes die by multiple mechanisms in failing human hearts
المؤلفون:
René Zimmermann , Jutta Schaper , Erwin P. Bauer , Hannes C.A. Drexler , Albrecht Elsässer , Stefan Hein , Yukihiro Hayakawa , Wolf-Peter Klövekorn , Lieven Pool , Eyal Arnon , Sawa Kostin
المصدر:
Circulation research . 92(7)
سنة النشر:
2003
مصطلحات موضوعية:
Cardiomyopathy, Dilated , medicine.medical_specialty , Programmed cell death , Proteasome Endopeptidase Complex , Necrosis , Physiology , Ubiquitin-activating enzyme , Ubiquitin-Protein Ligases , Blotting, Western , Apoptosis , Ubiquitin-Activating Enzymes , Ubiquitin-conjugating enzyme , Cathepsin D , Ligases , Ubiquitin , Multienzyme Complexes , Internal medicine , Idiopathic dilated cardiomyopathy , Carbon-Nitrogen Lyases , medicine , Autophagy , In Situ Nick-End Labeling , Humans , Myocytes, Cardiac , Microscopy, Immunoelectron , Microscopy, Confocal , biology , Cell biology , Cysteine Endopeptidases , Endocrinology , Ubiquitin-Conjugating Enzymes , biology.protein , medicine.symptom , Cardiology and Cardiovascular Medicine
الوصف:
We tested the hypothesis that myocyte loss in failing human hearts occurs by different mechanisms: apoptosis, oncosis, and autophagic cell death. Explanted hearts from 19 patients with idiopathic dilated cardiomyopathy (EF≤20%) and 7 control hearts were analyzed. Myocyte apoptosis revealed by caspase-3 activation and TUNEL staining occurred at a rate of 0.002±0.0005% ( P P P P P
تدمد:
1524-4571
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e16e7d7f785c3bcf79388a055e5b53 https://pubmed.ncbi.nlm.nih.gov/12702641
حقوق:
OPEN
رقم الأكسشن:
edsair.doi.dedup.....b7e16e7d7f785c3bcf79388a055e5b53
قاعدة البيانات:
OpenAIRE
