Carbogenic Nanozyme with Ultrahigh Reactive Nitrogen Species Selectivity for Traumatic Brain Injury

التفاصيل البيبلوغرافية
العنوان: Carbogenic Nanozyme with Ultrahigh Reactive Nitrogen Species Selectivity for Traumatic Brain Injury
المؤلفون: Changlong Liu, Xiaodong Zhang, Qifeng Li, Jiang Yang, Jingya Wang, Lufei Ouyang, Yalong Gao, Xiaoyu Mu, Wenping Hu, Si Sun, Haile Liu, Junying Wang, Qinjuan Ren, Wei Long, Qiang Liu, Yuan-Ming Sun, Hua He
المصدر: Nano Letters. 19:4527-4534
بيانات النشر: American Chemical Society (ACS), 2019.
سنة النشر: 2019
مصطلحات موضوعية: Antioxidant, Lipopolysaccharide, medicine.medical_treatment, chemistry.chemical_element, Bioengineering, 02 engineering and technology, Peroxide, Oxygen, Mice, chemistry.chemical_compound, Biomimetic Materials, Brain Injuries, Traumatic, medicine, Animals, General Materials Science, Reactive nitrogen species, chemistry.chemical_classification, Reactive oxygen species, Glutathione Disulfide, Mechanical Engineering, Hydrogen Peroxide, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Ascorbic acid, Reactive Nitrogen Species, Nanostructures, Disease Models, Animal, chemistry, Acute Disease, Biophysics, Glutathione disulfide, 0210 nano-technology
الوصف: Reactive oxygen and nitrogen species (RONS), especially reactive nitrogen species (RNS) are intermediate products during incidence of nervous system diseases, showing continuous damage for traumatic brain injury (TBI). Here, we developed a carbogenic nanozyme, which shows an antioxidant activity 12 times higher than ascorbic acid (AA) and behaves as multienzyme mimetics. Importantly, the nanozyme exhibits an ultrahigh scavenging efficiency (∼16 times higher than AA) toward highly active RNS, such as •NO and ONOO- as well as traditional reactive oxygen species (ROS) including O2•-, H2O2, and •OH. In vitro experiments show that neuron cells injured by H2O2 or lipopolysaccharide can be significantly recovered after carbogenic nanozyme treatment via scavenging all kinds of RONS. Moreover, the carbogenic nanozyme can serve as various enzyme mimetics and eliminate the harmful peroxide and glutathione disulfide from injured mice, demonstrating its potential as a therapeutic for acute TBI.
تدمد: 1530-6992
1530-6984
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e5c3b6fa199cb34397adcf429c765d
https://doi.org/10.1021/acs.nanolett.9b01333
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....b7e5c3b6fa199cb34397adcf429c765d
قاعدة البيانات: OpenAIRE