Consensus Recommendations for the Diagnosis of Vitreoretinal Lymphoma
| العنوان: | Consensus Recommendations for the Diagnosis of Vitreoretinal Lymphoma |
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| المؤلفون: | Denise Carbonell, Rupesh Agrawal, H. Nida Sen, Daniel Vitor Vasconcelos-Santos, Mamta Agarwal, Elisabetta Miserocchi, Sarah E. Coupland, Jacob Pe'er, Luca Cimino, Manabu Mochizuki, James T. Rosenbaum, Tracy T. Batchelor, Manfred Zierhut, Alejandra de-la-Torre, Massimo Accorinti, Bianka Sobolewska, Sarakshi Mahajan, Justine R. Smith, Soon-Phaik Chee, Tanja Bülow, Zohar Habot-Wilner, Helmut Sitter, Michael Simion, Vishali Gupta, Shahar Frenkel, Thomas Ness, Jennifer E. Thorne, Jose S. Pulido, Michal Kramer, Nicholas P Jones, Ninette H. ten Dam-van Loon, Jyotirmay Biswas |
| المصدر: | Ocular Immunology and Inflammation. 29:507-520 |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Delphi Technique, Lymphoma, genetic structures, diagnosis, DNA Mutational Analysis, Myeloid differentiation primary response, chemistry.chemical_compound, 0302 clinical medicine, consensus recommendations, Vitreoretinal lymphoma, Biomarkers, Tumor, Humans, Interleukin-10, Interleukin-6, Intraocular Lymphoma, Lymphoma, Large B-Cell, Diffuse, Mutation, Missense, Myeloid Differentiation Factor 88, Retinal Neoplasms, Retrospective Studies, Surveys and Questionnaires, Vitreous Body, Immunology and Allergy, Tumor, Diffuse, medicine.anatomical_structure, medicine.medical_specialty, 03 medical and health sciences, Retinal pigment epithelium atrophy, Ophthalmology, Large B-Cell, medicine, Macular edema, 030203 arthritis & rheumatology, Retina, business.industry, Diagnostic vitrectomy, Retinal, medicine.disease, eye diseases, Fundus autofluorescence, chemistry, Mutation, 030221 ophthalmology & optometry, Missense, business, Biomarkers |
| الوصف: | Purpose To provide recommendations for diagnosis of vitreoretinal lymphoma (VRL). Methods Literature was reviewed for reports supporting the diagnosis of VRL. A questionnaire (Delphi 1 round) was distributed to 28 participants. In the second round (Delphi 2), items of the questionnaire not reaching consensus (75% agreement) were discussed to finalize the recommendations. Results Presenting symptoms include floaters and painless loss of vision, vitreous cells organized into sheets or clumps. Retinal lesions are usually multifocal creamy/white in the outer retina. Other findings include retinal lesions with "leopard-skin" appearance and retinal pigment epithelium atrophy. Severe vitreous infiltration without macular edema is the most likely presentation. Diagnostic vitrectomy should be performed. Systemic corticosteroid should be discontinued at least 2 weeks before surgery. An interleukin (IL)-10:IL-6 ratio > 1, positive mutation for the myeloid differentiation primary response 88 gene and monoclonality are indicators of VRL. Multi-modal imaging (optical coherence tomography, fundus autofluorescence) are recommended. Conclusions A consensus meeting allowed the establishment of recommendations important for the diagnosis of VRL. |
| تدمد: | 1744-5078 0927-3948 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80a43974c0d9ca51fa2a7d00968c10e https://doi.org/10.1080/09273948.2021.1878233 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b80a43974c0d9ca51fa2a7d00968c10e |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17445078 09273948 |
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