Variable expression of podocyte-related markers in the glomeruloid bodies in Wilms tumor
| العنوان: | Variable expression of podocyte-related markers in the glomeruloid bodies in Wilms tumor |
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| المؤلفون: | Michio Nagata, Yujing Shu, Joichi Usui, Katsuyoshi Kanemoto, Kunimasa Yan, Yutaka Hamazaki, Shinsuke Tomari, Shori Takahashi |
| المصدر: | Pathology International. 53:596-601 |
| بيانات النشر: | Wiley, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, Sialoglycoproteins, Kidney Glomerulus, Muscle Proteins, Wilms Tumor, Tight Junctions, Pathology and Forensic Medicine, Podocyte, Nephrin, chemistry.chemical_compound, Cytokeratin, Biomarkers, Tumor, medicine, Humans, WT1 Proteins, biology, Tight junction, Microfilament Proteins, Infant, Membrane Proteins, Proteins, Wilms' tumor, General Medicine, medicine.disease, Kidney Neoplasms, medicine.anatomical_structure, Proto-Oncogene Proteins c-bcl-2, Podocalyxin, chemistry, biology.protein, Keratins, Immunohistochemistry, Female, Synaptopodin |
| الوصف: | Several podocyte-related markers are organized to express in glomerular differentiation. However, whether expression of them is virtually synchronized and a reliable indicator of the state of differentiation is unknown. The present study investigated, by immunohistochemistry, the divergent expression of several podocyte markers in the improperly differentiated glomeruloid bodies from four cases of Wilms tumors. The glomeruloid bodies were classified into immature (IGB) or mature forms (MGB) based on morphology and epithelial features. Podocytes in IGB expressed WT1, synaptopodin, podocalyxin, and nephrin, and their expression was stronger in MGB. In contrast, Pax2 was strong in IGB and diminished in MGB. p27 was first expressed in MGB. The expression pattern in each molecule mimics normal glomerulogenesis. Podocytes in MGB showed persistent expression of bcl-2 and cytokeratin with synaptopodin, podocalyxin, and nephrin by serial section, a finding unusual for normal glomerulogenesis. Moreover, parietal cells in MGB also occasionally expressed these podocyte markers. The ultrastructure revealed that podocytes in MGB showed tight junctions without foot process formations, which indicated incomplete differentiation. These results suggest that a set of podocyte differentiation markers are occasionally diversely expressed, and raise the possibility that expression of these markers is insufficient to determine the state of terminal differentiation in podocytes. |
| تدمد: | 1440-1827 1320-5463 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8727ec1dca54e54c6b05d368f5ece40 https://doi.org/10.1046/j.1440-1827.2003.01526.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....b8727ec1dca54e54c6b05d368f5ece40 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14401827 13205463 |
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