The in-vitro susceptibilities of vaginal lactobacilli to four broad-spectrum antibiotics, as determined by the agar dilution and E test methods
| العنوان: | The in-vitro susceptibilities of vaginal lactobacilli to four broad-spectrum antibiotics, as determined by the agar dilution and E test methods |
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| المؤلفون: | C.T. Keane, C. M. Herra, M. T. Cafferkey |
| المصدر: | Journal of Antimicrobial Chemotherapy. 35:775-783 |
| بيانات النشر: | Oxford University Press (OUP), 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Microbiology (medical), food.ingredient, medicine.drug_class, Antibiotics, Microbial Sensitivity Tests, Biology, Microbiology, Agar dilution, food, Clarithromycin, polycyclic compounds, medicine, Humans, Agar, Pharmacology (medical), Reagent Strips, Antibacterial agent, Pharmacology, biochemical phenomena, metabolism, and nutrition, Antimicrobial, Anti-Bacterial Agents, Culture Media, Ciprofloxacin, Lactobacillus, Infectious Diseases, Vagina, Female, Cefaclor, medicine.drug |
| الوصف: | The minimum inhibitory concentrations (MICs) of cefaclor, co-amoxiclav, clarithromycin and ciprofloxacin for 59 strains of vaginal lactobacilli were determined by both the reference agar dilution and E test methods. With the exception of clarithromycin, there was poor correlation between the results obtained by the two techniques. This was most apparent for the β-lactams studied, the MICs of cefaclor as determined by the E test being particularly difficult to define. The stability of antimicrobial gradients in the E test may cause problems when testing slow-growing bacteria and/or organisms which grow only under anaerobic conditions. Accordingly, only those MICs determined by the agar dilution method are reported. The percentages of susceptible isolates were as follows : clarithromycin, 100 ; co-amoxiclav, 100 ; cefaclor, 20 ; and ciprofloxacin, 4. The administration of antimicrobials, such as ciprofloxacin and cefaclor, which have poor activities in vitro against lactobacilli, may therefore be advantageous to the host because it allows the protective effects of the normal vaginal flora to be preserved. |
| تدمد: | 1460-2091 0305-7453 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8853b84deb43c87105863acae45294b https://doi.org/10.1093/jac/35.6.775 |
| رقم الأكسشن: | edsair.doi.dedup.....b8853b84deb43c87105863acae45294b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602091 03057453 |
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