Use of Flutemetamol F18-Labeled Positron Emission Tomography and Other Biomarkers to Assess Risk of Clinical Progression in Patients With Amnestic Mild Cognitive Impairment
| العنوان: | Use of Flutemetamol F18-Labeled Positron Emission Tomography and Other Biomarkers to Assess Risk of Clinical Progression in Patients With Amnestic Mild Cognitive Impairment |
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| المؤلفون: | Roger Bullock, Adrian Ivanoiu, Clive Holmes, Marilyn S. Albert, Michelle Zanette, Christopher Buckley, Jose Gamez, Juha O. Rinne, Eric Salmon, G. Farrar, Ranjan Duara, Kirk A. Frey, Andrea Cherubini, Marc Agronin, Jiong Shi, Eric Triau, Carl H. Sadowsky, Paul Sherwin, Zuzana Walker, Beth Safirstein, Marwan N. Sabbagh, Paul Loughlin, David A. Wolk, Lennart Minthon, Richard Perry, Steen G. Hasselbalch, Peter Høgh, Adam S. Fleisher, Fraser Inglis, Andrea Bozoki |
| المساهمون: | UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurologie |
| المصدر: | JAMA Neurology 75 (2018): 1114–1123. doi:10.1001/jamaneurol.2018.0894 info:cnr-pdr/source/autori:Wolk, David A.; Sadowsky, Carl; Safirstein, Beth; Rinne, Juha O.; Duara, Ranjan; Perry, Richard; Agronin, Marc; Gamez, Jose; Shi, Jiong; Ivanoiu, Adrian; Minthon, Lennart; Walker, Zuzana; Hasselbalch, Steen; Holmes, Clive; Sabbagh, Marwan; Albert, Marilyn; Fleisher, Adam; Loughlin, Paul; Triau, Eric; Frey, Kirk; Hogh, Peter; Bozoki, Andrea; Bullock, Roger; Salmon, Eric; Farrar, Gillian; Buckley, Christopher J.; Zanette, Michelle; Sherwin, Paul F.; Cherubini, Andrea; Inglis, Fraser/titolo:Use of Flutemetamol F18-Labeled Positron Emission Tomography and Other Biomarkers to Assess Risk of Clinical Progression in Patients With Amnestic Mild Cognitive Impairment/doi:10.1001%2Fjamaneurol.2018.0894/rivista:JAMA Neurology/anno:2018/pagina_da:1114/pagina_a:1123/intervallo_pagine:1114–1123/volume:75 JAMA Neurology, Vol. 75, no. 9, p. 1114-1123 (2018) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, alzheimer, ta3112, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Risk Factors, Internal medicine, mental disorders, medicine, Humans, Cognitive Dysfunction, Flutemetamol F 18, Benzothiazoles, Stage (cooking), Survival analysis, Original Investigation, Aged, Amyloid beta-Peptides, Aniline Compounds, medicine.diagnostic_test, Proportional hazards model, business.industry, Hazard ratio, Brain, medicine.disease, MCI, 030104 developmental biology, PET, Positron emission tomography, Positron-Emission Tomography, Disease Progression, Female, Amnesia, Neurology (clinical), Alzheimer's disease, business, Biomarkers, 030217 neurology & neurosurgery, Cohort study |
| الوصف: | Importance: Patients with amnestic mild cognitive impairment (aMCI) may progress to clinical Alzheimer disease (AD), remain stable, or revert to normal. Earlier progression to AD among patients who were β-amyloid positive vs those who were β-amyloid negative has been previously observed. Current research now accepts that a combination of biomarkers could provide greater refinement in the assessment of risk for clinical progression. Objective: To evaluate the ability of flutemetamol F 18 and other biomarkers to assess the risk of progression from aMCI to probable AD. Design, Setting, and Participants: In this multicenter cohort study, from November 11, 2009, to January 16, 2014, patients with aMCI underwent positron emission tomography (PET) at baseline followed by local clinical assessments every 6 months for up to 3 years. Patients with aMCI (365 screened; 232 were eligible) were recruited from 28 clinical centers in Europe and the United States. Physicians remained strictly blinded to the results of PET, and the standard of truth was an independent clinical adjudication committee that confirmed or refuted local assessments. Flutemetamol F 18-labeled PET scans were read centrally as either negative or positive by 5 blinded readers with no knowledge of clinical status. Statistical analysis was conducted from February 19, 2014, to January 26, 2018. Interventions: Flutemetamol F 18-labeled PET at baseline followed by up to 6 clinical visits every 6 months, as well as magnetic resonance imaging and multiple cognitive measures. Main Outcomes and Measures: Time from PET to probable AD or last follow-upwas plotted as a Kaplan-Meier survival curve; PET scan results, age, hippocampal volume, and aMCI stage were entered into Cox proportional hazards logistic regression analyses to identify variables associated with progression to probable AD. Results: Of 232 patients with aMCI (118 women and 114 men; mean [SD] age, 71.1 [8.6] years), 98 (42.2%) had positive results detected on PET scan. By 36 months, the rates of progression to probable AD were 36.2% overall (81 of 224 patients), 53.6%(52 of 97) for patients with positive results detected on PET scan, and 22.8% (29 of 127) for patients with negative results detected on PET scan. Hazard ratios for association with progression were 2.51 (95% CI, 1.57-3.99; P < .001) for a positive β-amyloid scan alone (primary outcome measure), 5.60 (95%CI, 3.14-9.98; P < .001) with additional low hippocampal volume, and 8.45 (95%CI, 4.40-16.24; P < .001) when poorer cognitive status was added to the model. Conclusions and Relevance: A combination of positive results of flutemetamol F 18-labeled PET, low hippocampal volume, and cognitive status corresponded with a high probability of risk of progression from aMCI to probable AD within 36 months. (Less) |
| اللغة: | English |
| DOI: | 10.1001/jamaneurol.2018.0894 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b887517374fda290287c07b0622b9323 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b887517374fda290287c07b0622b9323 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.1001/jamaneurol.2018.0894 |
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