Lipoprotein distribution and serum concentrations of 7α-hydroxy-4-cholesten-3-one and bile acids

التفاصيل البيبلوغرافية
العنوان: Lipoprotein distribution and serum concentrations of 7α-hydroxy-4-cholesten-3-one and bile acids
المؤلفون: Anne Tybjærg-Hansen, Ratna Karuna, Katharina Rentsch, Jan Albert Kuivenhoven, Adriaan G. Holleboom, Lucia Rohrer, Ruth Frikke-Schmidt, M. Mahdi Motazacker, Arnold von Eckardstein, Carine Steiner
المساهمون: Vascular Medicine, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Amsterdam Cardiovascular Sciences, Human Genetics, Experimental Vascular Medicine, University of Zurich, von Eckardstein, Arnold, Cardiovascular Centre (CVC), Lifestyle Medicine (LM), Vascular Ageing Programme (VAP), Center for Liver, Digestive and Metabolic Diseases (CLDM)
المصدر: Clinical science (London, England, 122(7-8), 385-396. Portland Press Ltd.
Clinical Science, 122(8), 385-400. PORTLAND PRESS LTD
Clinical science (London England : 1979)
بيانات النشر: PORTLAND PRESS LTD, 2012.
سنة النشر: 2012
مصطلحات موضوعية: Very low-density lipoprotein, Scavenger Receptors, Denmark, 2700 General Medicine, 030204 cardiovascular system & hematology, Phosphatidylcholine-Sterol O-Acyltransferase, chemistry.chemical_compound, 0302 clinical medicine, High-density lipoprotein, 540 Chemistry, 10038 Institute of Clinical Chemistry, 0303 health sciences, biology, Inborn Errors, Reverse cholesterol transport, General Medicine, Scavenger Receptors, Class B, lipids (amino acids, peptides, and proteins), Lipoproteins, HDL, ATP Binding Cassette Transporter 1, medicine.medical_specialty, HDL, Lipoproteins, education, 610 Medicine & health, Bile Acids and Salts, 03 medical and health sciences, 7α-Hydroxy-4-cholesten-3-one, Internal medicine, Cholesterylester transfer protein, medicine, Humans, Cholestenones, 030304 developmental biology, Apolipoprotein A-I, nutritional and metabolic diseases, Lipase, SCARB1, Cholesterol Ester Transfer Proteins, Endocrinology, Metabolism, chemistry, Case-Control Studies, Mutation, biology.protein, ATP-Binding Cassette Transporters, Hepatic lipase, Class B, Metabolism, Inborn Errors, Lipoprotein
الوصف: BA (bile acid) formation is considered an important final step in RCT (reverse cholesterol transport). HDL (high-density lipoprotein) has been reported to transport BAs. We therefore investigated the effects of monogenic disturbances in human HDL metabolism on serum concentrations and lipoprotein distributions of the major 15 BA species and their precursor C4 (7α-hydroxy-4-cholesten-3-one). In normolipidaemic plasma, approximately 84%, 11% and 5% of BAs were recovered in the LPDS (lipoprotein-depleted serum), HDL and the combined LDL (low-density lipoprotein)/VLDL (very-low-density lipoproteins) fraction respectively. Conjugated BAs were slightly over-represented in HDL. For C4, the respective percentages were 23%, 21% and 56% (41% in LDL and 15% in VLDL) respectively. Compared with unaffected family members, neither HDL-C (HDL-cholesterol)-decreasing mutations in the genes APOA1 [encoding ApoA-I (apolipoprotein A-I], ABCA1 (ATP-binding cassette transporter A1) or LCAT (lecithin:cholesterol acyltransferase) nor HDL-C-increasing mutations in the genes CETP (cholesteryl ester transfer protein) or LIPC (hepatic lipase) were associated with significantly different serum concentrations of BA and C4. Plasma concentrations of conjugated and secondary BAs differed between heterozygous carriers of SCARB1 (scavenger receptor class B1) mutations and unaffected individuals (P
اللغة: English
تدمد: 0143-5221
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e506ca7c903f4310eb12a340f2ed06
https://doi.org/10.1042/CS20110482
حقوق: RESTRICTED
رقم الأكسشن: edsair.doi.dedup.....b8e506ca7c903f4310eb12a340f2ed06
قاعدة البيانات: OpenAIRE