Spontaneous pain, pain threshold, and pain tolerance in Parkinson’s disease
| العنوان: | Spontaneous pain, pain threshold, and pain tolerance in Parkinson’s disease |
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| المؤلفون: | Antonella Macerollo, Serena Recchia, Roberta Vitaliani, Giovanni Defazio, Michele Tinazzi, Giuseppe Moretto, Corrado Marchini, Antonio Fiaschi, Sandro Zambito Marsala, Federico Fabris, Bruno Giometto |
| المساهمون: | Marsala, Sz, Tinazzi, M, Vitaliani, R, Recchia, S, Fabris, F, Marchini, C, Fiaschi, A, Moretto, G, Giometto, B, Macerollo, A, Defazio, G |
| المصدر: | Journal of Neurology. 258:627-633 |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Pain Threshold, medicine.medical_specialty, Neurology, Pain tolerance, Pain, Severity of Illness Index, Sensory threshold, Threshold of pain, medicine, Humans, Aged, Pain Measurement, Parkinson’s disease, pain, pain threshold, pain tolerance, business.industry, Beck Depression Inventory, Chronic pain, Parkinson Disease, Middle Aged, medicine.disease, Dyskinesia, Sensory Thresholds, Anesthesia, Female, Pain catastrophizing, Neurology (clinical), medicine.symptom, business |
| الوصف: | The mechanisms underlying pain in Parkinson's disease (PD) are unclear. Although a few studies have reported that PD patients may have low pain threshold and tolerance, none could accurately assess whether there was a correlation between sensory thresholds and demographic/clinical features of PD patients. Thus, tactile threshold, pain threshold, and pain tolerance to electrical stimuli in the hands and feet were assessed in 106 parkinsonian patients (of whom 66 reported chronic pain) and 51 age- and sex-matched healthy subjects. Linear regression models determined relationships between psychophysical parameters and demographic/clinical features. Female gender, severity of disease, medical disease associated with painful symptoms, and dyskinesia were more frequently observed in PD patients experiencing pain, even though dyskinesia did not reach significance. Pain threshold and pain tolerance were significantly lower in PD patients than in control subjects, whereas the tactile threshold yielded comparable values in both groups. Multivariable linear regression analyses yielded significant inverse correlations of pain threshold and pain tolerance with motor symptom severity and Beck depression inventory. Pain threshold and pain tolerance did not differ between PD patients with and without pain. In the former group, there was no relationship between pain threshold and the intensity/type of pain, and number of painful body parts. These findings suggest that pain threshold and pain tolerance tend to decrease as PD progresses, which can predispose to pain development. Female gender, dyskinesia, medical conditions associated with painful symptoms, and postural abnormalities secondary to rigidity/bradikinesia may contribute to the appearance of spontaneous pain in predisposed subjects. |
| تدمد: | 1432-1459 0340-5354 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f25b96b5b5cbf512b8d288bd8cbda0 https://doi.org/10.1007/s00415-010-5812-0 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b8f25b96b5b5cbf512b8d288bd8cbda0 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321459 03405354 |
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