التفاصيل البيبلوغرافية
العنوان:
Immune evasion of SARS-CoV-2 variants of concern is driven by low affinity to neutralizing antibodies
المؤلفون:
Emerson G. Moreira , Matheus V. F. Ferraz , Danilo F. Coêlho , Gabriel Luz Wallau , Roberto D. Lins
المصدر:
Chemical communications (Cambridge, England) . 57(49)
سنة النشر:
2021
مصطلحات موضوعية:
Models, Molecular , 2019-20 coronavirus outbreak , Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) , Protein domain , Static Electricity , Electrostatic surface potential , Antibody Affinity , Cross Reactions , Catalysis , 03 medical and health sciences , 0302 clinical medicine , Low affinity , Immune system , Protein Domains , Materials Chemistry , 030304 developmental biology , Immune Evasion , 0303 health sciences , biology , Chemistry , SARS-CoV-2 , Metals and Alloys , General Chemistry , Evasion (ethics) , Virology , Antibodies, Neutralizing , Surfaces, Coatings and Films , Electronic, Optical and Magnetic Materials , Spike Glycoprotein, Coronavirus , Ceramics and Composites , biology.protein , Antibody , 030217 neurology & neurosurgery
الوصف:
SARS-CoV-2 VOC immune evasion is mainly due to lower cross-reactivity from previously elicited class I/II neutralizing antibodies, while increased affinity to hACE2 plays a minor role. The affinity between antibodies and VOCs is impacted by remodeling of the electrostatic surface potential of the Spike RBDs. The P.3 variant is a putative VOC.
تدمد:
1364-548X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f2c7d20d2f7cfd50cd2c391c192fa8 https://pubmed.ncbi.nlm.nih.gov/34037640
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....b8f2c7d20d2f7cfd50cd2c391c192fa8
قاعدة البيانات:
OpenAIRE
