The use of 5-ALA to assist complete removal of residual non-enhancing part of childhood medulloblastoma: a case report
| العنوان: | The use of 5-ALA to assist complete removal of residual non-enhancing part of childhood medulloblastoma: a case report |
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| المؤلفون: | Jane Skjøth-Rasmussen, Karsten Nysom, Astrid Sehested, Lars Bøgeskov, Helle Broholm, Camilla Klausen |
| المصدر: | Child's Nervous System. 31:2173-2177 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, medicine.medical_treatment, Neurosurgical Procedures, medicine, Adjuvant therapy, Humans, Radical surgery, Stage (cooking), Cerebellar Neoplasms, Child, Dexamethasone, Medulloblastoma, Photosensitizing Agents, business.industry, Aminolevulinic Acid, General Medicine, medicine.disease, Combined Modality Therapy, Magnetic Resonance Imaging, Surgery, Radiation therapy, Regimen, Pediatrics, Perinatology and Child Health, Neurology (clinical), Neurosurgery, business, Follow-Up Studies, medicine.drug |
| الوصف: | Medulloblastoma is the most common malignant brain tumor in childhood. Radical surgery in the non-metastatic stage is an important factor with respect to overall survival. In this case, 5-aminolevulinic acid (5-ALA) was used at second-look surgery in order to improve surgical results. The child was pretreated with 3 × 4 mg dexamethasone for 4 days prior to the second surgery. At 5 a.m. on the day of surgery, a freshly prepared solution of 5-ALA (20 mg/kg body weight; Medac, Germany) was given orally. At surgery, through the original opening, the vague red fluorescence of the tumor was clearly distinctive from the cerebellum with no tumor infiltration. All fluorescent tissue was removed. Postoperative MRI gave suspicion of yet at small tumor residue, but this structure is less than 1.5 ml in calculated volume, and consequently the recommended adjuvant therapy of the child changed from the high-risk medulloblastoma regimen to the standard-risk regimen. In this particular difficult case of non-contrast-enhancing tumor, 5-ALA was of vital importance to improve rate of resection and change the aggressiveness needed in postsurgery radiation therapy. |
| تدمد: | 1433-0350 0256-7040 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9310344bd77830851a4658718e27d51 https://doi.org/10.1007/s00381-015-2762-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....b9310344bd77830851a4658718e27d51 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14330350 02567040 |
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