Redesigning nucleic acids
| العنوان: | Redesigning nucleic acids |
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| المؤلفون: | Heike A. Held, J. J. Vögel, Andrew L. Roughton, Thomas R. Battersby, J. T. Kodra, Michael J. Lutz, Joseph Stackhouse, Krishnan P. Nambiar, Daniel Hutter, Klaus Schneider, Martin Egli, Joseph A. Piccirilli, Christophe Hammer, Simon E. Moroney, Steven A. Benner, Jennifer Horlacher, L. J. MacPherson, U. von Krosigk, Tuncer Arslan, D. K. Bäschlin, Clemens Richert, Jurgen G. Schmidt, Stefan Lutz, Simona C. Jurczyk, Bernd Eschgfäller, Christopher Switzer, Thomas F. Jenny, E. Müller, H. A. König, M. Blättler, Birgitte Hyrup, Zh. Huang |
| المصدر: | Pure and Applied Chemistry. 70:263-266 |
| بيانات النشر: | Walter de Gruyter GmbH, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Molecular Structure, Oligonucleotide, Chemistry, General Chemical Engineering, Oligonucleotides, RNA, DNA, General Chemistry, Computational biology, Catalysis, Phosphates, chemistry.chemical_compound, Nucleic Acids, Nucleic acid, Organic chemistry, Sulfones, Codon, Molecular Biology |
| الوصف: | A research program has applied the tools of synthetic organic chemistry to systematically modify the structure of DNA and RNA oligonucleotides to learn more about the chemical principles underlying their ability to store and transmit genetic information. Oligonucleotides (as opposed to nucleosides) have long been overlooked by synthetic organic chemists as targets for structural modification. Synthetic chemistry has now yielded oligonucleotides with 12 replicatable letters, modified backbones, and new insight into why Nature chose the oligonucleotide structures that she did. |
| تدمد: | 1365-3075 0033-4545 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b940b7d75ddb946ff93654a2ab04b0c1 https://doi.org/10.1351/pac199870020263 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b940b7d75ddb946ff93654a2ab04b0c1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13653075 00334545 |
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