Mobilization and transplantation of Philadelphia-negative peripheral-blood progenitor cells early in chronic myelogenous leukemia
| العنوان: | Mobilization and transplantation of Philadelphia-negative peripheral-blood progenitor cells early in chronic myelogenous leukemia |
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| المؤلفون: | P Carlier, A. Dejana, A. M. Carella, Francesco Frassoni, C. Parodi, O. Figari, M Abote, Mario Sessarego, E. Prencipe, Enrica Lerma, A M Gatti, D. Van Den Berg, Federica Benvenuto, I. Cunningham, M Valbonesi, F Vassallo, F. Chimirri, R Hoffman, L. Celesti, Marina Podestà |
| المصدر: | Journal of Clinical Oncology. 15:1575-1582 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Antineoplastic Agents, Pilot Projects, Transplantation, Autologous, Gastroenterology, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Internal medicine, medicine, Humans, Idarubicin, Philadelphia Chromosome, Progenitor cell, Interferon alfa, Etoposide, Chemotherapy, business.industry, Hematopoietic Stem Cell Transplantation, Interferon-alpha, Middle Aged, Hematopoietic Stem Cells, medicine.disease, Transplantation, Treatment Outcome, Oncology, Immunology, Cytarabine, Female, business, medicine.drug, Chronic myelogenous leukemia |
| الوصف: | PURPOSE Mobilization of Philadelphia (Ph) chromosome-negative progenitors is now possible in many Ph1-positive chronic myelogenous leukemia (CML) patients who had received interferon alfa (IFN-alpha) with no cytogenetic response. In this pilot study, we used this approach in patients without prior IFN-alpha therapy to determine if the number and quality of mobilized progenitors would be increased and to evaluate the potential effect of these cells as autografts. PATIENTS AND METHODS Twenty-two untreated patients were mobilized within 12 months of diagnosis. The treatment regimen consisted of the mini-ICE protocol. Beginning on day +8, granulocyte colony-stimulating factor (G-CSF) was used in all patients. Leukophoresis was performed as the patients were recovering from aplasia, when WBC count exceeded 0.8 x 10(9)/L. RESULTS In 14 patients, (63%) the leukophoresis product was entirely Ph1-negative and in four patients the Ph1-positive cell rate was < or = 7%. Significant numbers of long-term culture-initiating cells (LTC-IC) and CD34+ Thy1+Lin- cells were found in most of the Ph1-negative collections that were tested. Twelve patients underwent autografting with their mobilized peripheral-blood progenitor cells (PBPC) (Ph1-negative collections, 10 patients; major cytogenetic response, two patients). All patients engrafted and are alive; six have Ph1-negative marrow 7 to 15 months after autografting. Posttransplant treatment was IFN-alpha combined with interleukin (IL)-2 because of the recent demonstration of synergistic activity in augmenting cytolytic activity. CONCLUSION Intensive chemotherapy given in early chronic phase of CML is well tolerated and results in high numbers of circulating Ph1-negative precursor cells. |
| تدمد: | 1527-7755 0732-183X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b969359540de8bb7907bacd8c7753c1b https://doi.org/10.1200/jco.1997.15.4.1575 |
| رقم الأكسشن: | edsair.doi.dedup.....b969359540de8bb7907bacd8c7753c1b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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