Electrochemical TEMPO-Catalyzed Oxidative Ugi-Type Reaction
| العنوان: | Electrochemical TEMPO-Catalyzed Oxidative Ugi-Type Reaction |
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| المؤلفون: | Na Pan, Maegan Xinen Lee, Maxime R. Vitale, Laurence Grimaud, Louis Bunel |
| المساهمون: | Laboratoire des biomolécules (LBM UMR 7203), Chimie Moléculaire de Paris Centre (FR 2769), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Département de Chimie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), East China Normal University [Shangaï] (ECNU), VITALE, Maxime R. |
| المصدر: | ACS Organic & Inorganic Au ACS Organic & Inorganic Au, 2021, 1, pp.18-22. ⟨10.1021/acsorginorgau.1c00003⟩ ACS Organic & Inorganic Au, Vol 1, Iss 1, Pp 18-22 (2021) |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cultural Studies, History, Literature and Literary Theory, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Chemistry, Isocyanide, Organic chemistry, Oxidative phosphorylation, [CHIM.ORGA] Chemical Sciences/Organic chemistry, Electrosynthesis, Electrochemistry, Combinatorial chemistry, Indirect anodic oxidation, Catalysis, chemistry.chemical_compound, QD241-441, Oxidative Ugi reaction, TEMPO, human activities, Inorganic chemistry, Muticomponent reaction, QD146-197 |
| الوصف: | International audience; Oxidative isocyanide-based multicomponent reactions (oxidative IMCRs) are very useful tools for the rapid construction of molecular diversity starting from readily available and stable substrates. Despite all their benefits, such multicomponent reactions are underdeveloped and strictly limited to 3component processes. Indeed, in the presence of several reaction partners, the oxidation event needs to be rigorously chemoselective, which becomes incredibly more intricate as the number of reactive components increases. Nonetheless, we could overcome this significant pitfall and reach the first oxidative Ugi-type 4-IMCR by capitalizing on a very mild and green TEMPO-catalyzed electro-oxidation process. Employing alcohols as aldehyde surrogates and in the notable absence of any supporting electrolyte, this transformation proved to be extremely chemoselective in the presence of an amine and was compatible with a wide range of alcohols, amines, isocyanides, and carboxylic acids. |
| وصف الملف: | application/pdf |
| تدمد: | 2694-247X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98bde988c8042079f0badb3be94c8be https://doi.org/10.1021/acsorginorgau.1c00003 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b98bde988c8042079f0badb3be94c8be |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2694247X |
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