Ocular surface squamous neoplasia: Population demographics, pathogenesis and risk factors
| العنوان: | Ocular surface squamous neoplasia: Population demographics, pathogenesis and risk factors |
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| المؤلفون: | Roland Höllhumer, Pamela Michelow, Susan Williams |
| المصدر: | African Vision and Eye Health, Vol 79, Iss 1, Pp e1-e8 (2020) |
| بيانات النشر: | AOSIS, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Conjunctival Neoplasm, ultraviolet radiation, medicine.medical_specialty, 030231 tropical medicine, Human immunodeficiency virus (HIV), medicine.disease_cause, Metastasis, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, lcsh:Ophthalmology, squamous cell cancer, medicine, human papillomavirus, Ultraviolet radiation, human immunodeficiency virus, business.industry, HPV infection, medicine.disease, Dermatology, lcsh:RE1-994, Disease Presentation, 030221 ophthalmology & optometry, conjunctival neoplasm, business, Ocular surface |
| الوصف: | Background: Ocular surface squamous neoplasia (OSSN) is a unifying term used to describe conjunctival intra-epithelial neoplasia, squamous cell carcinoma in situ and invasive squamous cell carcinoma. Aim: The aim of this article was to describe the demographics, clinical features, pathogenesis and risk factors of OSSN. Method: A literature search was conducted using the search criteria ‘ocular surface squamous neoplasia’, ‘diagnosis’, ‘epidemiology’, ‘pathogenesis’ and ‘risk factors’. Results: Ocular surface squamous neoplasia is the most common ocular tumour, with incidence rates ranging from 0.01 to 3.4 per 100 000 persons/year. There are two main patterns of disease presentation: older white males in temperate climates where human immunodeficiency virus (HIV) and human papilloma virus (HPV) are not associated; and a younger patient population in tropical climates where HIV and HPV are more prevalent. The pathogenesis primarily revolves around ultraviolet B exposure and HPV infection that cause genetic mutations and uncontrolled cellular proliferation, whilst HIV infection and vitamin A impair tumour surveillance mechanisms. Ocular surface squamous neoplasia is first suspected clinically before formal confirmation of the diagnosis. Morphologically, it can be divided into three groups: placoid, nodular and diffuse. Placoid lesions can further be sub-divided into gelatinous, leukoplakic and papilliform lesions. Nodular lesions have the poorest prognosis, with the highest risk of metastasis and recurrence. Conclusion: Ocular surface squamous neoplasia is a common ocular tumour associated with ultraviolet radiation, HPV and HIV infection. The pathogenesis revolves around acquired genetic mutations, unregulated cellular proliferation and impaired tumour surveillance mechanisms. |
| تدمد: | 2410-1516 2413-3183 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ca70c71089b70f4c37810378552ea3 https://doi.org/10.4102/aveh.v79i1.553 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b9ca70c71089b70f4c37810378552ea3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24101516 24133183 |
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