Short and mid‐term SARS‐CoV‐2 antibody response after inactivated COVID‐19 vaccine in hemodialysis and kidney transplant patients
العنوان: | Short and mid‐term SARS‐CoV‐2 antibody response after inactivated COVID‐19 vaccine in hemodialysis and kidney transplant patients |
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المؤلفون: | Hamad Dheir, Aysel Tocoglu, Hande Toptan, Musa Pinar, Taner Demirci, Mehmet Koroglu, Selcuk Yaylaci, Ahmed Bilal Genc, Ahmed Cihad Genc, Necattin Firat, Oguz Karabay, Savas Sipahi |
المصدر: | Journal of Medical Virology. 94:3176-3183 |
بيانات النشر: | Wiley, 2022. |
سنة النشر: | 2022 |
مصطلحات موضوعية: | COVID-19 Vaccines, Infectious Diseases, Renal Dialysis, SARS-CoV-2, Virology, Antibody Formation, COVID-19, Humans, Antibodies, Viral, Kidney Transplantation |
الوصف: | The efficacy of the inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine has not been fully elucidated across the whole spectrum of patients on kidney replacement therapy. We aimed to characterize the long-term antibody response of inactivated SARS-CoV-2 vaccine administered in kidney transplant recipients (KTRs) and hemodialysis (HD) patients. We performed this prospective observational study in 50 HD, 64 KTR, and 41 healthy control groups (HG) given two doses of CoronaVac. We measured anti-Spike antibodies after 28 days of every vaccine dose, 3rd and 6th months after the first dose, and compared them between cohorts. After two doses, an anti-spike immunoglobulin G of ≥50 AU/ml was present in HD, KTR, and HG as 44%, 7.2%, and 58.5%, respectively (p 0.001). Furthermore, the proportion of antibody titers peaked at 86.5%, 23%, and 97.6% (p 0.001) at the 3rd month and decreased significantly at the 6th month in most HD and HG participants, whereas this effect was not observed in KTRs from basal until the 6th month (p 0.001). During the follow-up, the incidence of coronavirus disease 2019 disease was higher (p 0.003) in KTRs compared to the other groups, but there was no requirement for an intensive care unit and no death was recorded. We found a negative correlation between antibody seroconversion and age (p 0.016). The antibody response following inactivated vaccine in dialysis patients is almost comparable to controls for 6 months. In contrast, kidney transplant patients have a poor response. These findings reinforce the need to discuss the vaccination strategy in immunocompromised patients, including the third dose with homologous or heterologous vaccines. |
تدمد: | 1096-9071 0146-6615 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e0e0d3d21622f69b27b1d744c21fe9 https://doi.org/10.1002/jmv.27714 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi.dedup.....b9e0e0d3d21622f69b27b1d744c21fe9 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 10969071 01466615 |
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