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SUN-PO316: Impact of Protein Intake and High-Fat Diet on Muscle Protein Synthesis and Lipid Infiltration in Relation to Aging in Rats

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العنوان: SUN-PO316: Impact of Protein Intake and High-Fat Diet on Muscle Protein Synthesis and Lipid Infiltration in Relation to Aging in Rats
المؤلفون: B. Yves, A. Carayon, O. LeBacquer, F. Sanchez, Jérôme Salles, Stéphane Walrand, Frédéric Capel, S. de Saint-Vincent, Christophe Giraudet, F. Rossignon, Eleonora Poggiogalle, Jean-Paul Rigaudière, Christelle Guillet
المساهمون: Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Nutrition Clinique, CHU Clermont-Ferrand, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]
المصدر: Clinical Nutrition
Clinical Nutrition, 2019, 38 (Supplement 1), pp.S176-S176. ⟨10.1016/S0261-5614(19)32946-2⟩
Clinical Nutrition, Elsevier, 2019, 38 (Supplement 1), pp.S176-S176. ⟨10.1016/S0261-5614(19)32946-2⟩
بيانات النشر: HAL CCSD, 2019.
سنة النشر: 2019
مصطلحات موضوعية: 2. Zero hunger, Muscle protein, 0303 health sciences, medicine.medical_specialty, Nutrition and Dietetics, 030309 nutrition & dietetics, business.industry, 030209 endocrinology & metabolism, High fat diet, Critical Care and Intensive Care Medicine, medicine.disease, Protein intake, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, business, Infiltration (medical), [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
الوصف: Part of special issue: Abstracts of the 41st ESPEN Congress, Krakow, Poland, 31 August–3 September, 2019; International audience; Rationale: Ectopic lipid deposition impairs muscle anabolic responseespecially during aging. We hypothesized that the anabolic efficiencyof dietary protein in skeletal muscle might be affected by high-fat diet.The objective of the study was to investigate muscle protein synthesisin response totwolevels of protein intake combined totwo levels of fatintake. Methods: Two groups of sixty adult and forty-nine old male Wistarrats were randomly divided into four groups: isocaloric standard diet (12% protein, 14% lipid, as STD12); isocaloric standard (high-protein)diet (25% protein, 14% lipid, STD25); hypercaloric high-fat (normal-protein) diet (12% protein, 45% lipid, HFD12); and hypercaloric high-fat (high-protein) diet (25% protein, 45% lipid, HFD25). The nutritionalintervention lasted 10 weeks. The fractional synthesis (FSR) andabsolute synthesis rates (ASR) of mixed muscle proteins werecalculated using isotopically labelled13C-Valine incorporation intibialis anterior (TA). Muscle lipid content was assessed usingchromatography method. Results: Rats in the high-fat diet groups self-limited their food intake,so that energy intake was not different among the groups. Regardlessof dietary intervention, TAweight was lower in old groups compared totheir adult counterparts (all p values Conclusions: Aging is characterized by reduced muscleweight despiteincreased FSR, suggesting specific alterations in the nutritionalregulation of muscle protein turnover. In isocaloric conditions, higherprotein intake modulates muscle lipid infiltration, without improvingage-related anabolic resistance in old rats fed a high-fat diet.
اللغة: English
تدمد: 0261-5614
1532-1983
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f8cdd9562602b873f0e705addad4e3
https://hal.inrae.fr/hal-02624728
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....b9f8cdd9562602b873f0e705addad4e3
قاعدة البيانات: OpenAIRE
الوصف
تدمد:02615614
15321983