The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial
| العنوان: | The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial |
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| المؤلفون: | Adriaan A. Voors, Christiane E. Angermann, John R. Teerlink, Sean P. Collins, Mikhail Kosiborod, Jan Biegus, João Pedro Ferreira, Michael E. Nassif, Mitchell A. Psotka, Jasper Tromp, C. Jan Willem Borleffs, Changsheng Ma, Joseph Comin-Colet, Michael Fu, Stefan P. Janssens, Robert G. Kiss, Robert J. Mentz, Yasushi Sakata, Henrik Schirmer, Morten Schou, P. Christian Schulze, Lenka Spinarova, Maurizio Volterrani, Jerzy K. Wranicz, Uwe Zeymer, Shelley Zieroth, Martina Brueckmann, Jonathan P. Blatchford, Afshin Salsali, Piotr Ponikowski |
| المساهمون: | Cardiovascular Centre (CVC) |
| المصدر: | Nature Medicine, 28(3), 568-574. Nature Publishing Group Voors, A A, Angermann, C E, Teerlink, J R, Collins, S P, Kosiborod, M, Biegus, J, Ferreira, J P, Nassif, M E, Psotka, M A, Tromp, J, Borleffs, C J W, Ma, C, Comin-Colet, J, Fu, M, Janssens, S P, Kiss, R G, Mentz, R J, Sakata, Y, Schirmer, H, Schou, M, Schulze, P C, Spinarova, L, Volterrani, M, Wranicz, J K, Zeymer, U, Zieroth, S, Brueckmann, M, Blatchford, J P, Salsali, A & Ponikowski, P 2022, ' The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure : a multinational randomized trial ', Nature Medicine, vol. 28, no. 3, pp. 568-574 . https://doi.org/10.1038/s41591-021-01659-1 |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Heart Failure, HF, MORTALITY, Stroke Volume, General Medicine, Ventricular Function, Left, General Biochemistry, Genetics and Molecular Biology, Hospitalization, Diabetes Mellitus, Type 2, Double-Blind Method, Glucosides, Humans, Benzhydryl Compounds, Sodium-Glucose Transporter 2 Inhibitors |
| الوصف: | The sodium–glucose cotransporter 2 inhibitor empagliflozin reduces the risk of cardiovascular death or heart failure hospitalization in patients with chronic heart failure, but whether empagliflozin also improves clinical outcomes when initiated in patients who are hospitalized for acute heart failure is unknown. In this double-blind trial (EMPULSE; NCT04157751), 530 patients with a primary diagnosis of acute de novo or decompensated chronic heart failure regardless of left ventricular ejection fraction were randomly assigned to receive empagliflozin 10 mg once daily or placebo. Patients were randomized in-hospital when clinically stable (median time from hospital admission to randomization, 3 days) and were treated for up to 90 days. The primary outcome of the trial was clinical benefit, defined as a hierarchical composite of death from any cause, number of heart failure events and time to first heart failure event, or a 5 point or greater difference in change from baseline in the Kansas City Cardiomyopathy Questionnaire Total Symptom Score at 90 days, as assessed using a win ratio. More patients treated with empagliflozin had clinical benefit compared with placebo (stratified win ratio, 1.36; 95% confidence interval, 1.09–1.68; P = 0.0054), meeting the primary endpoint. Clinical benefit was observed for both acute de novo and decompensated chronic heart failure and was observed regardless of ejection fraction or the presence or absence of diabetes. Empagliflozin was well tolerated; serious adverse events were reported in 32.3% and 43.6% of the empagliflozin- and placebo-treated patients, respectively. These findings indicate that initiation of empagliflozin in patients hospitalized for acute heart failure is well tolerated and results in significant clinical benefit in the 90 days after starting treatment. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1078-8956 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2772007a16a0ae82a7d40c0345bc5f https://research.rug.nl/en/publications/70f50ca3-ed7b-44eb-9f1b-e25050dbf5cd |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ba2772007a16a0ae82a7d40c0345bc5f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10788956 |
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