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Diet-induced insulin resistance state disturbs brain clock processes and alters tuning of clock outputs in the Sand rat, Psammomys obesus

التفاصيل البيبلوغرافية
العنوان: Diet-induced insulin resistance state disturbs brain clock processes and alters tuning of clock outputs in the Sand rat, Psammomys obesus
المؤلفون: Etienne Challet, Saliha Ouali-Hassenaoui, Paul Pévet, Patrick Vuillez, Hanane Touati, Aicha Dekar-Madoui
المساهمون: Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Brain Research
Brain Research, Elsevier, 2018, 1679, pp.116-124. ⟨10.1016/j.brainres.2017.11.018⟩
بيانات النشر: Elsevier BV, 2018.
سنة النشر: 2018
مصطلحات موضوعية: Dietary Fiber, 0301 basic medicine, medicine.medical_specialty, Vasopressins, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Vasoactive intestinal peptide, Circadian clock, CLOCK Proteins, Biology, Eating, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Biological Clocks, Internal medicine, medicine, Hyperinsulinemia, Animals, Circadian rhythm, Molecular Biology, ComputingMilieux_MISCELLANEOUS, General Neuroscience, Insulin, Body Weight, Brain, medicine.disease, biology.organism_classification, Dietary Fats, Diet, 030104 developmental biology, Endocrinology, Gene Expression Regulation, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), Psammomys, Insulin Resistance, Gerbillinae, Somatostatin, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery, Vasoactive Intestinal Peptide, Developmental Biology
الوصف: Reciprocal interactions closely connect energy metabolism with circadian rhythmicity. Altered clockwork and circadian desynchronization are often linked with impaired energy regulation. Conversely, metabolic disturbances have been associated with altered autonomic and hormonal rhythms. The effects of high-energy (HE) diet on the master clock in the suprachiasmatic nuclei (SCN) remain unclear.This question was addressed in the Sand rat (Psammomys obesus), a non-insulin-dependent diabetes mellitus (NIDDM) animal model. The aim of this work was to determine whether enriched diet in Psammomys affects locomotor activity rhythm, as well as daily oscillations in the master clock of the SCN and in an extra-SCN brain oscillator, the piriform cortex. Sand rats were fed during 3 months with either low or HE diet. Vasoactive intestinal peptide (VIP), vasopressin (AVP) and CLOCK protein cycling were studied by immunohistochemistry and running wheel protocol was used for behavioral analysis. High energy feeding dietary triggered hyperinsulinemia, impaired insulin/glucose ratio and disruption in pancreatic hormonal rhythms. Circadian disturbances in hyper-insulinemic animals include a lengthened rest/activity rhythm in constant darkness, as well as disappearance of daily rhythmicity of VIP, AVP and the circadian transcription factor CLOCK within the suprachiasmatic clock. In addition, daily rhythmicity of VIP and CLOCK was abolished by HE diet in a secondary brain oscillator, the piriform cortex. Our findings highlight a major impact of diabetogenic diet on central and peripheral rhythmicity. The Psammomys model will be instrumental to better understand the functional links between circadian clocks, glucose intolerance and insulin resistance state.
تدمد: 0006-8993
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3b8e12ac4289257189794cb42620fe
https://doi.org/10.1016/j.brainres.2017.11.018
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....ba3b8e12ac4289257189794cb42620fe
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00068993