The Effect of Seratrodast on Eosinophil Cationic Protein and Symptoms in Asthmatics
| العنوان: | The Effect of Seratrodast on Eosinophil Cationic Protein and Symptoms in Asthmatics |
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| المؤلفون: | Toshihiko Fukuoka, Naohiko Inase, Takeshi Umino, Naoko Tojo, Shuji Miyake, Yasuyuki Yoshizawa |
| المصدر: | Journal of Asthma. 40:257-264 |
| بيانات النشر: | Informa UK Limited, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Adult, Male, Pulmonary and Respiratory Medicine, medicine.drug_class, Peak Expiratory Flow Rate, Pharmacology, Thromboxane A2, chemistry.chemical_compound, Ribonucleases, Bronchodilator, Benzoquinones, Humans, Immunology and Allergy, Medicine, Anti-Asthmatic Agents, Asthma, Eosinophil cationic protein, Cross-Over Studies, business.industry, Sputum, Blood Proteins, Eosinophil Granule Proteins, respiratory system, Seratrodast, medicine.disease, Crossover study, respiratory tract diseases, Eosinophils, chemistry, Heptanoic Acids, Bronchial hyperresponsiveness, Pediatrics, Perinatology and Child Health, Immunology, Female, Bronchial Hyperreactivity, Inflammation Mediators, medicine.symptom, business |
| الوصف: | Thromboxane A2 (TXA2), an arachidonate derivative, is a potent bronchoconstrictor; therefore, blocking TXA2 should attenuate airway narrowing. Seratrodast, a TXA2 receptor antagonist, is expected to be a potent antiasthmatic. It was reported that seratrodast reduced bronchial hyperresponsiveness. However, it is controversial whether it reduces airway inflammation. We studied some additional effects of oral seratrodast to inhaled corticosteroids on 10 adult asthmatics in an open-label, crossover design study. Eosinophil cationic protein (ECP) levels in serum and sputum, peak expiratory flow rate (PEF), clinical symptoms, and airway responsiveness were evaluated. Clinical symptom scores were improved by administration of seratrodast (p < 0.05). The addition of seratrodast to asthmatic patients significantly improved mean PEF (p < 0.05). In addition, withdrawal of seratrodast resulted in deterioration of PEF. Airway hyperresponsiveness to acetylcholine measured by Astograph was improved by administration of seratrodast (p < 0.01), and returned to the level of "run-in period" after withdrawal. Administration of seratrodast decreased the concentration of ECP in sputum significantly (p < 0.05), and sputum ECP significantly increased again after withdrawal of (p < 0.05). These results suggest that seratrodast improves clinical symptoms andairway hyperresponsiveness by reducing airway inflammation. Seratrodast may be useful as an anti-inflammatory agent and beneficial when added to inhaled corticosteroids in the treatment of bronchial asthma. |
| تدمد: | 1532-4303 0277-0903 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba52dc26e20fe2570bc781821af5581b https://doi.org/10.1081/jas-120018322 |
| رقم الأكسشن: | edsair.doi.dedup.....ba52dc26e20fe2570bc781821af5581b |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15324303 02770903 |
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