DDX53 Regulates Cancer Stem Cell-Like Properties by Binding to SOX-2
| العنوان: | DDX53 Regulates Cancer Stem Cell-Like Properties by Binding to SOX-2 |
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| المؤلفون: | Youngmi Kim, Dooil Jeoung, Minjeong Yeon |
| المصدر: | Molecules and Cells |
| بيانات النشر: | Korean Society for Molecular and Cellular Biology, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, DDX53, Paclitaxel, Tumor spheroid, Biology, Article, DEAD-box RNA Helicases, 03 medical and health sciences, chemistry.chemical_compound, Antigen, Cancer stem cell, Cell Line, Tumor, microRNA, medicine, Animals, Humans, AC133 Antigen, Molecular Biology, SOX-2, Melanoma, Mice, Inbred BALB C, SOXB1 Transcription Factors, Cancer, anti-cancer drug-resistance, Cell Biology, General Medicine, medicine.disease, Antineoplastic Agents, Phytogenic, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, cancer stem cell-like properties, MicroRNAs, 030104 developmental biology, chemistry, Drug Resistance, Neoplasm, embryonic structures, Cancer research, Neoplastic Stem Cells, Female, AC133 antigen |
| الوصف: | This study investigated the role of cancer/testis antigen DDX53 in regulating cancer stem cell-like properties. DDX53 shows co-expression with CD133, a marker for cancer stem cells. DDX53 directly regulates the SOX-2 expression in anticancer drug-resistant Malme3MR cells. DDX53 and miR-200b were found to be involved in the regulation of tumor spheroid forming potential of Malme3M and Malme3MR cells. Furthermore, the self-renewal activity and the tumorigenic potential of Malme3MR-CD133 (+) cells were also regulated by DDX53. A miR-200b inhibitor induced the direct regulation of SOX-2 by DDX53 We therefore, conclude that DDX53 may serve as an immunotherapeutic target for regulating cancer stem-like properties of melanomas. |
| اللغة: | English |
| تدمد: | 0219-1032 1016-8478 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8f5323a2524d25fd4e31d9acfca872 http://europepmc.org/articles/PMC5463040 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ba8f5323a2524d25fd4e31d9acfca872 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02191032 10168478 |
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