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Polymorphisms of the KCNQ1 gene are associated with the therapeutic responses of sulfonylureas in Chinese patients with type 2 diabetes

التفاصيل البيبلوغرافية
العنوان: Polymorphisms of the KCNQ1 gene are associated with the therapeutic responses of sulfonylureas in Chinese patients with type 2 diabetes
المؤلفون: Xiang Cheng, Feng Jiang, Qing Li, Rong Zhang, Miao Chen, Yuqian Bao, Weiping Jia, Jun Yin, Ting-ting Tang, Cheng Hu
المصدر: Acta pharmacologica Sinica. 38(1)
سنة النشر: 2016
مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, medicine.medical_specialty, China, endocrine system diseases, Genotype, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, Type 2 diabetes, Gastroenterology, Polymorphism, Single Nucleotide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Asian People, Internal medicine, medicine, Humans, Pharmacology (medical), Gliclazide, Allele, Alleles, Pharmacology, Genetics, Glycated Hemoglobin, business.industry, Homozygote, Type 2 Diabetes Mellitus, General Medicine, Odds ratio, Middle Aged, medicine.disease, 030104 developmental biology, Sulfonylurea Compounds, Treatment Outcome, chemistry, Diabetes Mellitus, Type 2, KCNQ1 Potassium Channel, Female, Original Article, Glycated hemoglobin, business, medicine.drug
الوصف: KCNQ1 channel is a member of the voltage-gated potassium channel KQT-like subfamily. The KCNQ1 gene has recently been identified as a susceptibility locus for type 2 diabetes mellitus (T2DM). In the present study, we examined the effects of KCNQ1 variants on the therapeutic response to modified-release gliclazide (gliclazide MR) treatment in Chinese patients newly diagnosed with T2DM. A total of 100 newly diagnosed T2DM patients without a history of any anti-diabetic medications were treated with gliclazide MR for 16 weeks, but 91 patients completed the entire study. The anthropometric parameters were determined at baseline and at the final visit, while clinical laboratory tests were performed at baseline and on weeks 2, 4, 6, 12, 16. Two SNPs, rs2237892 and rs2237895, in the region of the KCNQ1 gene were genotyped in all the participants. All calculations and statistical analyses were conducted using SPSS. The rs2237892 TT homozygotes exhibited significantly higher 2-h glucose levels at baseline (P
تدمد: 1745-7254
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba92fd2d82556c1fed456f6619682742
https://pubmed.ncbi.nlm.nih.gov/27694910
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....ba92fd2d82556c1fed456f6619682742
قاعدة البيانات: OpenAIRE
الوصف
تدمد:17457254