Old plasma dilution reduces human biological age: a clinical study
| العنوان: | Old plasma dilution reduces human biological age: a clinical study |
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| المؤلفون: | Daehwan Kim, Dobri D. Kiprov, Connor Luellen, Michael Lieb, Chao Liu, Etsuko Watanabe, Xiaoyue Mei, Kaitlin Cassaleto, Joel Kramer, Michael J. Conboy, Irina M. Conboy |
| المصدر: | GeroScience. 44:2701-2720 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Proteomics, Aging, Clinical Research, Inflammatory and immune system, Biological noise, Genetics, Rejuvenation, 2.1 Biological and endogenous factors, Plasmapheresis, Aetiology, Geriatrics and Gerontology, Lymphoid/myeloid markers, Biotechnology |
| الوصف: | Abstract This work extrapolates to humans the previous animal studies on blood heterochronicity and establishes a novel direct measurement of biological age. Our results support the hypothesis that, similar to mice, human aging is driven by age-imposed systemic molecular excess, the attenuation of which reverses biological age, defined in our work as a deregulation (noise) of 10 novel protein biomarkers. The results on biological age are strongly supported by the data, which demonstrates that rounds of therapeutic plasma exchange (TPE) promote a global shift to a younger systemic proteome, including youthfully restored pro-regenerative, anticancer, and apoptotic regulators and a youthful profile of myeloid/lymphoid markers in circulating cells, which have reduced cellular senescence and lower DNA damage. Mechanistically, the circulatory regulators of the JAK-STAT, MAPK, TGF-beta, NF-κB, and Toll-like receptor signaling pathways become more youthfully balanced through normalization of TLR4, which we define as a nodal point of this molecular rejuvenation. The significance of our findings is confirmed through big-data gene expression studies. |
| وصف الملف: | application/pdf |
| تدمد: | 2509-2723 2509-2715 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babf387ba2fd66dac689a3ad01f017b3 https://doi.org/10.1007/s11357-022-00645-w |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....babf387ba2fd66dac689a3ad01f017b3 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 25092723 25092715 |
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