Aminoglycoside-induced lipotoxicity and its reversal in kidney on chip
| العنوان: | Aminoglycoside-induced lipotoxicity and its reversal in kidney on chip |
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| المؤلفون: | Konstantinos Ioannidis, Aaron Cohen, Mohammad Ghosheh, Avner Ehrlich, Amit Fischer, Merav Cohen, Yaakov Nahmias |
| المصدر: | Lab on a Chip. 22:4469-4480 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Kidney Tubules, Proximal, Aminoglycosides, Biomedical Engineering, Humans, Bioengineering, General Chemistry, Gentamicins, Kidney, Biochemistry, Anti-Bacterial Agents |
| الوصف: | Aminoglycosides are an important class of antibiotics that play a critical role in the treatment of life-threatening infections, but their use is limited by their toxicity. In fact, gentamicin causes severe nephrotoxicity in 17% of hospitalized patients. The kidney proximal tubule is particularly vulnerable to drug-induced nephrotoxicity due to its role in drug transport. In this work, we developed a perfused vascularized model of human kidney tubuloids integrated with tissue-embedded microsensors that track the metabolic dynamics of aminoglycoside-induced renal toxicity in real time. Our model shows that gentamicin disrupts proximal tubule polarity at concentrations 20-fold below its TC |
| تدمد: | 1473-0189 1473-0197 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac6a2f910172db0433dee43ccaaeb47 https://doi.org/10.1039/d2lc00825d |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....bac6a2f910172db0433dee43ccaaeb47 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14730189 14730197 |
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