Detecting the Potential for Consciousness in Unresponsive Patients Using the Perturbational Complexity Index
| العنوان: | Detecting the Potential for Consciousness in Unresponsive Patients Using the Perturbational Complexity Index |
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| المؤلفون: | S. N. Morozova, Dmitry Yu. Lagoda, Yulia V. Ryabinkina, Alexandra G. Poydasheva, A. Comanducci, Anastasia N. Sergeeva, Ilya S. Bakulin, Natalia A. Suponeva, Liudmila A. Legostaeva, Silvia Casarotto, Elena I. Kremneva, Michael A. Piradov, D. Sergeev, Elizaveta G. Iazeva, Dmitry O. Sinitsyn |
| المصدر: | Brain Sciences; Volume 10; Issue 12; Pages: 917 Brain Sciences, Vol 10, Iss 917, p 917 (2020) Brain Sciences |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, diagnosis, medicine.medical_treatment, media_common.quotation_subject, Population, Disorders of consciousness, Electroencephalography, Article, lcsh:RC321-571, Internal medicine, transcranial magnetic stimulation, medicine, education, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, disorders of consciousness, perturbational complexity index, media_common, unresponsive wakefulness syndrome, education.field_of_study, reliability, medicine.diagnostic_test, business.industry, General Neuroscience, Minimally conscious state, medicine.disease, minimally conscious state, electroencephalography, Transcranial magnetic stimulation, surgical procedures, operative, Conventional PCI, Cardiology, Wakefulness, Consciousness, business |
| الوصف: | The difficulties of behavioral evaluation of prolonged disorders of consciousness (DOC) motivate the development of brain-based diagnostic approaches. The perturbational complexity index (PCI), which measures the complexity of electroencephalographic (EEG) responses to transcranial magnetic stimulation (TMS), showed a remarkable sensitivity in detecting minimal signs of consciousness in previous studies. Here, we tested the reliability of PCI in an independently collected sample of 24 severely brain-injured patients, including 11 unresponsive wakefulness syndrome (UWS), 12 minimally conscious state (MCS) patients, and 1 emergence from MCS patient. We found that the individual maximum PCI value across stimulation sites fell within the consciousness range (i.e., was higher than PCI*, which is an empirical cutoff previously validated on a benchmark population) in 11 MCS patients, yielding a sensitivity of 92% that surpassed qualitative evaluation of resting EEG. Most UWS patients (n = 7, 64%) showed a slow and stereotypical TMS-EEG response, associated with low-complexity PCI values (i.e., ≤PCI*). Four UWS patients (36%) provided high-complexity PCI values, which might suggest a covert capacity for consciousness. In conclusion, this study successfully replicated the performance of PCI in discriminating between UWS and MCS patients, further motivating the application of TMS-EEG in the workflow of DOC evaluation. |
| وصف الملف: | application/pdf |
| تدمد: | 2076-3425 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0b31e1f91410134442265f6620f876 https://doi.org/10.3390/brainsci10120917 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....bb0b31e1f91410134442265f6620f876 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763425 |
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